Immune Mechanisms of Rejection in Human Lung Allografts
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The investigators have obtained compelling evidence that the development of anti-human leukocyte antigen (anti-HLA) antibodies against mismatched donor antigens significantly correlates with the development of bronchiolitis obliterans (BOS). Further, these anti-HLA antibodies are developed at least 15 months prior to any clinical evidence of BOS. This lag period between the development of anti-HLA antibodies and the onset of BOS gives us an opportunity to intervene to delay and/or prevent the development of BOS.
The primary efficacy event is the change in pulmonary function testing values (FEV1). [ Time Frame: Lung function is monitored at regular intervals. Patients will be followed for five years. ]
Secondary Outcome Measures :
Secondary efficacy measurements include allograft and patient survival, incidence of BOS and Obliterative bronchiolitis. [ Time Frame: The subjects are monitored at regular intervals. Patients will be followed for five years. ]
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Ages Eligible for Study:
18 Years to 70 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Any patient who is a candidate for a lung transplant.
Lung transplant recipient.
Anyone who is unable or unwilling to consent to this study.