Renal Osteodystrophy: A Fresh Approach
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|ClinicalTrials.gov Identifier: NCT00859612|
Recruitment Status : Completed
First Posted : March 11, 2009
Last Update Posted : May 5, 2017
There are two major goals of this project:
- Comparison of DXA and QCT for diagnosis of bone loss in CKD-5 patients and determination of the prevalence of low bone turnover in CKD-5 patients with bone loss.
- Identification of the optimal combination of noninvasive tests for definition of the turnover component of ROD.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||464 participants|
|Official Title:||Renal Osteodystrophy: A Fresh Approach|
|Study Start Date :||March 2009|
|Primary Completion Date :||February 2014|
|Study Completion Date :||February 2014|
- Comparison of DXA and QCT for diagnosis of bone loss in CKD-5 patients and determination of the prevalence of low bone turnover in CKD-5 patients with bone loss. [ Time Frame: 4 years ]Because each method (QCT or DXA) yields a dichotomous response (bone loss: yes or no), the proportion of patients with a bone loss will be compared between the 2 methods by using the McNemar statistic for correlated proportions.
- Identification of the optimal combination of noninvasive tests for definition of the turnover component of ROD. [ Time Frame: 4 years ]A stepwise logistic model will be used to determine which combination of PTH and bone markers best predicts low bone turnover.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00859612
|United States, Kentucky|
|University of Kentucky|
|Lexington, Kentucky, United States, 40536|
|Principal Investigator:||Hartmut H Malluche, MD||University of Kentucky|