Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer: Concordance Study
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This study will examine genes in three different tissues and look for similarities and differences between normal cells and cancer cells. The tissues to be studies come from blood, lymph node and cancer.
Condition or disease
Subjects will be given an informed consent to read and sign The medical chart will be reviewed for diagnosis and treatment history Blood (about 4 tablespoons) will be drawn at a clinically available time. The lymph node and breast tumor tissue in the University of Michigan pathology repository will be used for research purposes
Single nucleotide polymorphisms [ Time Frame: time-independent ]
Determine single nucleotide polymorphism concordances between the three DNA specimen sources
Biospecimen Retention: Samples With DNA
Retained samples will consist of a portion of the specimens collected for this concordance study: peripheral blood leukocytes, lymph nodes, and tumor tissue. All retained samples will be completely de-identified and re-numbered.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
breast cancer patients
Age at least 18 years of age
Able to read and sign the informed consent
Able to provide specimens: one blood draw for white blood cells, provide permission to use tissue already collected.