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Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients (AAAS)
This study has been completed.
Sponsor:
Asan Medical Center
Information provided by:
Asan Medical Center
ClinicalTrials.gov Identifier:
NCT00856921
First received: March 5, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted
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Purpose
The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of tears). However, the genetic mechanism between achalasia and alacrima has not been defined yet. The investigators postulated that some proportions of early-onset achalasia could be correlated with AAAS gene; thus, the investigators aimed to investigate the relationship between the AAAS gene and early-onset achalasia.
| Condition |
|---|
| Achalasia Alacrima |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Retrospective |
| Official Title: | To Find Out the Genetic Relationship Between the Early-Onset Achalasia and AAAS Gene |
Resource links provided by NLM:
Further study details as provided by Asan Medical Center:
Primary Outcome Measures:
- Genetic relationship between achalasia and AAAS gene
Biospecimen Retention: Samples With DNA
DNA and genetic analysis
| Enrollment: | 19 |
| Study Start Date: | April 2008 |
| Study Completion Date: | March 2009 |
| Primary Completion Date: | January 2009 (Final data collection date for primary outcome measure) |
Eligibility| Ages Eligible for Study: | Child, Adult, Senior |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Early age onset achalasia
Criteria
Inclusion Criteria:
- early age onset
- primary achalasia patient
- less than 35 years old
Exclusion Criteria:
- secondary achalasia patients
Contacts and Locations
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No Contacts or Locations Provided
No Contacts or Locations Provided
More Information
| Responsible Party: | Kee Wook Jung, Asan Medical Center |
| ClinicalTrials.gov Identifier: | NCT00856921 History of Changes |
| Other Study ID Numbers: |
AAASachalasia |
| Study First Received: | March 5, 2009 |
| Last Updated: | March 5, 2009 |
Keywords provided by Asan Medical Center:
|
Relationship between achalasia and AAAS gene |
Additional relevant MeSH terms:
|
Esophageal Achalasia Esophageal Motility Disorders Deglutition Disorders |
Esophageal Diseases Gastrointestinal Diseases Digestive System Diseases |
ClinicalTrials.gov processed this record on September 19, 2017