Nerve Morphology in Diabetic Patients

This study has been completed.
Information provided by:
Skane University Hospital Identifier:
First received: March 4, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted
The underlying basis of carpal tunnel syndrome and the basis of its increased incidence in diabetes are unknown. The aim of this study was to quantified pathology in an uncompressed nerve (posterior interosseous nerve in the forearm between diabetic and non-diabetic patients with CTS.

Peripheral Neuropathy
Carpal Tunnel Syndrome
Entrapment Neuropathies
Diabetes Complications

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Posterior Interosseous Nerve Pathology May Provide Novel Insights Into Both Predisposition and Potential Vascular Basis for the Development of Carpal Tunnel Syndrome in Diabetic Patients.

Resource links provided by NLM:

Further study details as provided by Skane University Hospital:

Primary Outcome Measures:
  • Nerve morphology (Fascicular area, myelinated nerve fiber density, endoneurial capillary density and subperineurial space [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA
Biopsies of the posterior interosseous nerve

Enrollment: 46
Study Start Date: December 2003
Study Completion Date: April 2008
Diabetic patients with carpal tunnel syndrome
Non-diabetic patients with carpal tunnel syndrome


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients referred to a specialized hand clinic

Inclusion Criteria

  • Diagnosis of carpal tunnel syndrome based in clinical history and symptoms
  • Confirmed by nerve conduction studies

Exclusion Criteria

  • Other focal nerve entrapments
  • Cervical radiculopathy
  • Inflammatory joint disease
  • Renal failure
  • Thyroid disorders
  • Previous wrist fracture
  • Long-term exposure to vibrating tools
  • Age under 18
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Please refer to this study by its identifier: NCT00856011

Dept. of Hand Surgery, Malmo University Hospital
Malmo, Sweden, SE-205 02
Sponsors and Collaborators
Skane University Hospital
  More Information

Responsible Party: Niels Thomsen, MD Identifier: NCT00856011     History of Changes
Other Study ID Numbers: LU 508-03 (2003) 
Study First Received: March 4, 2009
Last Updated: March 4, 2009
Health Authority: Sweden: Regional Ethical Review Board

Additional relevant MeSH terms:
Charcot-Marie-Tooth Disease
Hereditary Sensory and Motor Neuropathy
Nerve Compression Syndromes
Carpal Tunnel Syndrome
Diabetes Complications
Peripheral Nervous System Diseases
Congenital Abnormalities
Cumulative Trauma Disorders
Diabetes Mellitus
Endocrine System Diseases
Genetic Diseases, Inborn
Heredodegenerative Disorders, Nervous System
Median Neuropathy
Nervous System Diseases
Nervous System Malformations
Neurodegenerative Diseases
Neuromuscular Diseases
Sprains and Strains
Wounds and Injuries processed this record on May 24, 2016