Parkinson's Disease Genetics Database

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00855556
Recruitment Status : Terminated (Enrollment into this registry was not as robust as investigator envisioned. Thus, the registry was closed.)
First Posted : March 4, 2009
Last Update Posted : September 16, 2015
Information provided by (Responsible Party):
Michael Pourfar, Northwell Health

Brief Summary:

The goal of the study is to develop and organize an effort to identify genes that determine an individual's risk for developing Parkinson's disease (PD).

  1. To ascertain, study and establish a repository of DNA samples that will allow for the identification of known and yet-to-be-identified genetic markers associated with the development of PD.
  2. To create a database with clinical, genetic (HLA, genome screen) and medical history information that will facilitate the search for PD susceptibility genes.
  3. To provide a centralized DNA repository to allow for targeted studies of genetic factors contributing to the onset, heterogeneity and progression of PD.
  4. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy for PD.

Condition or disease Intervention/treatment
Parkinson's Disease Genetic: blood draw

Study Type : Observational
Actual Enrollment : 16 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Parkinson's Disease Genetics Database
Study Start Date : February 2008
Actual Primary Completion Date : February 2013
Actual Study Completion Date : February 2013

Resource links provided by the National Library of Medicine

Intervention Details:
  • Genetic: blood draw

    The blood collection is designed to obtain blood samples as a source of DNA for genotyping and to establish a plasma and serum storage repository for future assays. GCRC nurses will perform all blood draws associated with this study. The following procedures are designed to standardize sample collection:

    1. Blood will be collected with the participant in the seated position with the reclining position reserved for those with a history of fainting during blood collection.
    2. Participants will be instructed to drink plenty of water (e.g., at least 8 large glasses of water) prior to the clinic visit as this facilitates easier collection.
    3. No fasting, activity or medication restrictions are required prior to or following blood collection.
    4. Blood collection will follow completion of the questionnaires. They will be performed by a nurse or technician with documented class time and experience in phlebotomy. Technician certification will occur prior to blood collection.

Primary Outcome Measures :
  1. the current protocol is for establishment of the registry only and not for particular analyses of its contents [ Time Frame: 5 years ]

Biospecimen Retention:   Samples With DNA
DNA stored in TE buffer solution

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Subjects with a diagnosis of Parkinson's Disease as determined by standard neurological criteria.

Inclusion Criteria:

  • Subjects must have a diagnosis of Parkinson's Disease as determined by standard neurological criteria.
  • Patients ≥18 years of age who are able to provide informed consent
  • Patients ≥ 18 who are decisionally impaired for whom informed consent can be obtained by a legally authorized representative.

Exclusion Criteria:

  • Patients without a diagnosis of Parkinson's Disease.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00855556

United States, New York
The Feinstein Institute for Medical Research
Manhasset, New York, United States, 11030
Sponsors and Collaborators
Northwell Health
Principal Investigator: Michael Pourfar, MD Northwell Health

Responsible Party: Michael Pourfar, Principal Investigator, Northwell Health Identifier: NCT00855556     History of Changes
Other Study ID Numbers: GCRC 0171
First Posted: March 4, 2009    Key Record Dates
Last Update Posted: September 16, 2015
Last Verified: September 2015

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases