Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain (ACUTE CT)
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The ACUTE CT trial is designed to test whether the assessment of chest structures by high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy for patient with acute chest pain or other potential cardiac symptoms as compared to a standard of care evaluation.
Adults at low to intermediate risk of acute coronary syndrome who present to the Emergency Department with symptoms suggestive of cardiac ischemia will undergo a blinded cardiac CT followed by a standard of care (SOC) strategy. Significant coronary artery disease on CT (coronary stenosis >50%) will be compared to an adjudicated diagnosis derived from clinical data and other diagnostic tests based on the SOC strategy. Costs for the SOC evaluation will be collected and compared to a CT-based evaluation. Patients will be followed for 3 years after enrollment to evaluate prognosis.
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Ages Eligible for Study:
30 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Alll patients presenting to the University of Washington Medical Center Emergency Department with possible acute coronary syndrome
Low to intermediate risk of angina with a TIMI ACS Risk Score ≤ 4
chest pain or other symptoms suggestive of ACS within 24 hours
male ≥30 years or female ≥45 years old
at least one cardiac risk factor
no obvious cause for symptoms.
ST segment elevation, new left bundle branch block or dynamic ECG changes