Primary Outcome Measures:
- Diagnostic accuracy of CT compared to standard of care evaluation [ Time Frame: 3 months ]
Secondary Outcome Measures:
- Cost savings of CT-based evaluation compared to the standard of care evaluation [ Time Frame: 3 months ]
Adults at low to intermediate risk of acute coronary syndrome who present to the Emergency Department with symptoms suggestive of cardiac ischemia will undergo a blinded cardiac CT followed by a standard of care (SOC) strategy. Significant coronary artery disease on CT (coronary stenosis >50%) will be compared to an adjudicated diagnosis derived from clinical data and other diagnostic tests based on the SOC strategy. Costs for the SOC evaluation will be collected and compared to a CT-based evaluation. Patients will be followed for 3 years after enrollment to evaluate prognosis.