The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels (WLMBL)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00854412
Recruitment Status : Completed
First Posted : March 3, 2009
Last Update Posted : March 3, 2009
Aarhus University Hospital
Information provided by:
University of Aarhus

Brief Summary:

High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and changes in insulin resistance on MBL levels have been poorly elucidated.

This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (VLCD) of 800 kcal/day for 8 weeks.

Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed using the HOMA-IR method.

Condition or disease Intervention/treatment Phase
Obesity Weight Loss Other: Weight loss Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 36 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: The Effect of Weight Loss on Serum Mannose-Binding Lectin (MBL) Levels
Study Start Date : March 1995
Actual Primary Completion Date : June 1995
Actual Study Completion Date : June 1995

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Intervention Details:
    Other: Weight loss
    Very low-calorie diet (VLCD) of 800 kcal/day for 8 weeks

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obese

Exclusion Criteria:

  • Diabetes
  • Other severe disease

Responsible Party: Pernille Høyem MD, PhD-student, Medical Department M, Aarhus University Hospital Identifier: NCT00854412     History of Changes
Other Study ID Numbers: MBL1
First Posted: March 3, 2009    Key Record Dates
Last Update Posted: March 3, 2009
Last Verified: March 2009

Keywords provided by University of Aarhus:
Weight loss
Very low-calorie diet
Mannose-binding lectin
Insulin resistance

Additional relevant MeSH terms:
Body Weight
Weight Loss
Signs and Symptoms
Body Weight Changes