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The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels (WLMBL)

This study has been completed.
Aarhus University Hospital
Information provided by:
University of Aarhus Identifier:
First received: March 2, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and changes in insulin resistance on MBL levels have been poorly elucidated.

This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (VLCD) of 800 kcal/day for 8 weeks.

Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed using the HOMA-IR method.

Condition Intervention
Weight Loss
Other: Weight loss

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Effect of Weight Loss on Serum Mannose-Binding Lectin (MBL) Levels

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Enrollment: 36
Study Start Date: March 1995
Study Completion Date: June 1995
Primary Completion Date: June 1995 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: Weight loss
    Very low-calorie diet (VLCD) of 800 kcal/day for 8 weeks

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obese

Exclusion Criteria:

  • Diabetes
  • Other severe disease
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No Contacts or Locations Provided
  More Information

Responsible Party: Pernille Høyem MD, PhD-student, Medical Department M, Aarhus University Hospital Identifier: NCT00854412     History of Changes
Other Study ID Numbers: MBL1
Study First Received: March 2, 2009
Last Updated: March 2, 2009

Keywords provided by University of Aarhus:
Weight loss
Very low-calorie diet
Mannose-binding lectin
Insulin resistance

Additional relevant MeSH terms:
Body Weight
Weight Loss
Signs and Symptoms
Body Weight Changes processed this record on May 25, 2017