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The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels (WLMBL)

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ClinicalTrials.gov Identifier: NCT00854412
Recruitment Status : Completed
First Posted : March 3, 2009
Last Update Posted : March 3, 2009
Information provided by:

Study Description
Brief Summary:

High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and changes in insulin resistance on MBL levels have been poorly elucidated.

This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (VLCD) of 800 kcal/day for 8 weeks.

Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed using the HOMA-IR method.

Condition or disease Intervention/treatment
Obesity Weight Loss Other: Weight loss

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 36 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: The Effect of Weight Loss on Serum Mannose-Binding Lectin (MBL) Levels
Study Start Date : March 1995
Primary Completion Date : June 1995
Study Completion Date : June 1995

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Intervention Details:
    Other: Weight loss
    Very low-calorie diet (VLCD) of 800 kcal/day for 8 weeks

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Obese

Exclusion Criteria:

  • Diabetes
  • Other severe disease
More Information

Responsible Party: Pernille Høyem MD, PhD-student, Medical Department M, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00854412     History of Changes
Other Study ID Numbers: MBL1
First Posted: March 3, 2009    Key Record Dates
Last Update Posted: March 3, 2009
Last Verified: March 2009

Keywords provided by University of Aarhus:
Weight loss
Very low-calorie diet
Mannose-binding lectin
Insulin resistance

Additional relevant MeSH terms:
Body Weight
Weight Loss
Signs and Symptoms
Body Weight Changes