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Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2011 by Katz, Sherri Lynne, M.D..
Recruitment status was:  Recruiting
Information provided by:
Katz, Sherri Lynne, M.D. Identifier:
First received: March 2, 2009
Last updated: July 18, 2011
Last verified: July 2011

Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death. While the complex interactions between obesity and OSA are not entirely clear, we hypothesize that these conditions may compound each other by:

  1. decreasing physical activity and total energy expenditure by reducing both non-exercise physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical activity.
  2. alterations in the secretion of appetite-controlling hormones, which may lead to increases in energy intake.

Objective: To determine whether the presence of both obesity and OSA in children is associated with a decrease in physical activity and alterations in appetite-regulating hormones greater than those seen in either condition alone or compared to controls.

Methods: Comparison of children 10-17 years with obesity and OSA, obesity alone, OSA alone and neither condition, for the following outcomes: (1) NEAT (kcal/day) (2) Physical activity behavior, appetite regulating hormone profile and self-report appetite assessment.

Unique Aspects: This study combines expertise in sleep medicine, exercise physiology and obesity. Conclusions from this study will better characterize this high-risk clinical population so that innovative strategies targeting improvements in lifestyle behaviors can be developed.

Childhood Obesity Childhood Obstructive Sleep Apnea

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Co-existent OSA and Obesity: Finding NEAT Targets for Intervention

Resource links provided by NLM:

Further study details as provided by Katz, Sherri Lynne, M.D.:

Primary Outcome Measures:
  • NEAT (kcal/day) [ Time Frame: 10 day period ]

Secondary Outcome Measures:
  • Physical activity behavior (minutes of moderate-vigorous physical activity as directly measured by accelerometry), appetite regulating hormone profile and self-report appetite assessment. [ Time Frame: 10 day period ]

Biospecimen Retention:   Samples Without DNA

Estimated Enrollment: 40
Study Start Date: September 2010
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Children with both obesity and obstructive sleep apnea
Children without the presence of both obesity and obstructive sleep apnea


Ages Eligible for Study:   10 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Subjects will be recruited from those scheduled to undergo polysomnography in the sleep laboratory at the Children's Hospital of Eastern Ontario

Inclusion Criteria:

  • age 10-17 years
  • coming for polysomnography at the Children's Hospital of Eastern Ontario

Exclusion Criteria:

  • children receiving treatment for OSA with CPAP (continuous positive airway pressure) or bi-level therapy
  • craniofacial abnormalities
  • genetic syndromes
  • neuromuscular disease
  • tracheostomy
  • medications that may affect appetite or energy balance (systemic corticosteroids)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00854334

Contact: Lynda Hoey, RN, CCRP 613-737-7600 ext 4109

Canada, Ontario
Childrens Hospital of Eastern Ontario Recruiting
Ottawa, Ontario, Canada, K1H 8L1
Principal Investigator: Sherri Katz         
Principal Investigator: Rachel Colley         
Sponsors and Collaborators
Katz, Sherri Lynne, M.D.
  More Information

Responsible Party: Dr. Sherri Katz, Children's Hospital of Eastern Ontario Identifier: NCT00854334     History of Changes
Other Study ID Numbers: Neat-OSA-001
Study First Received: March 2, 2009
Last Updated: July 18, 2011

Keywords provided by Katz, Sherri Lynne, M.D.:
Physical activity

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Pediatric Obesity
Nutrition Disorders
Body Weight
Signs and Symptoms
Respiration Disorders
Respiratory Tract Diseases
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on July 25, 2017