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Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention

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ClinicalTrials.gov Identifier: NCT00854334
Recruitment Status : Completed
First Posted : March 3, 2009
Last Update Posted : March 9, 2018
Sponsor:
Information provided by (Responsible Party):
Dr. Sherry Lynn Katz, Children's Hospital of Eastern Ontario

Brief Summary:

Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death. While the complex interactions between obesity and OSA are not entirely clear, we hypothesize that these conditions may compound each other by:

  1. decreasing physical activity and total energy expenditure by reducing both non-exercise physical pursuits (NEAT- non-exercise activity thermogenesis) and purposeful physical activity.
  2. alterations in the secretion of appetite-controlling hormones, which may lead to increases in energy intake.

Objective: To determine whether the presence of both obesity and OSA in children is associated with a decrease in physical activity and alterations in appetite-regulating hormones greater than those seen in either condition alone or compared to controls.

Methods: Comparison of children 10-17 years with obesity and OSA, obesity alone, OSA alone and neither condition, for the following outcomes: (1) NEAT (kcal/day) (2) Physical activity behavior, appetite regulating hormone profile and self-report appetite assessment.

Unique Aspects: This study combines expertise in sleep medicine, exercise physiology and obesity. Conclusions from this study will better characterize this high-risk clinical population so that innovative strategies targeting improvements in lifestyle behaviors can be developed.


Condition or disease
Childhood Obesity Childhood Obstructive Sleep Apnea

Study Type : Observational
Actual Enrollment : 9 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Co-existent OSA and Obesity: Finding NEAT Targets for Intervention
Study Start Date : September 2010
Actual Primary Completion Date : September 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sleep Apnea
U.S. FDA Resources

Group/Cohort
1.
Children with both obesity and obstructive sleep apnea
2
Children without the presence of both obesity and obstructive sleep apnea



Primary Outcome Measures :
  1. NEAT (kcal/day) [ Time Frame: 10 day period ]

Secondary Outcome Measures :
  1. Physical activity behavior (minutes of moderate-vigorous physical activity as directly measured by accelerometry), appetite regulating hormone profile and self-report appetite assessment. [ Time Frame: 10 day period ]

Biospecimen Retention:   Samples Without DNA
urine


Information from the National Library of Medicine

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Ages Eligible for Study:   10 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Subjects will be recruited from those scheduled to undergo polysomnography in the sleep laboratory at the Children's Hospital of Eastern Ontario
Criteria

Inclusion Criteria:

  • age 10-17 years
  • coming for polysomnography at the Children's Hospital of Eastern Ontario

Exclusion Criteria:

  • children receiving treatment for OSA with CPAP (continuous positive airway pressure) or bi-level therapy
  • craniofacial abnormalities
  • genetic syndromes
  • neuromuscular disease
  • tracheostomy
  • medications that may affect appetite or energy balance (systemic corticosteroids)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00854334


Locations
Canada, Ontario
Childrens Hospital of Eastern Ontario
Ottawa, Ontario, Canada, K1H 8L1
Sponsors and Collaborators
Katz, Sherri Lynne, M.D.

Responsible Party: Dr. Sherry Lynn Katz, Katz, Sherri Lynne, M.D., Children's Hospital of Eastern Ontario
ClinicalTrials.gov Identifier: NCT00854334     History of Changes
Other Study ID Numbers: Neat-OSA-001
First Posted: March 3, 2009    Key Record Dates
Last Update Posted: March 9, 2018
Last Verified: March 2018

Keywords provided by Dr. Sherry Lynn Katz, Children's Hospital of Eastern Ontario:
Sleep
Overweight
Physical activity
Appetite
NEAT

Additional relevant MeSH terms:
Obesity
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Pediatric Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Apnea
Respiration Disorders
Respiratory Tract Diseases
Sleep Disorders, Intrinsic
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases