Energy Expenditure in Weaning From Mechanical Ventilation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00853060
Recruitment Status : Completed
First Posted : February 27, 2009
Last Update Posted : February 27, 2009
Information provided by:
Hospital de Clinicas de Porto Alegre

Brief Summary:
During weaning from mechanical ventilation process, the energy expenditure in T tube is greater than pressure support ventilation.

Condition or disease
Respiration, Artificial Energy Metabolism

Detailed Description:
The energy expenditure (EE) was measured during the two periods of 30-minutes, with the 10 first minutes being discarded for analysis purposes. The other variables were recorded and monitored during the 10th and the 30th minute, in both pressure support (PS) and t-Tube (TT) modes. Patients were randomized in terms of sequence selection: PS - TT or TT - PS. In the baseline period, patients were receiving mechanical ventilation (Servo 900C and Servo 300; Siemens-Elema, Solna, Sweden), with PS ranging from 10 to 15cmH2O. During the PS mode, patients received assisted pressure ventilation of 10 cmH2O, 5 cmH2O of final positive expiratory pressure, the sensitivity of -1cmH2O and FiO2 of 0.4. During TT mode, oxygen flow was delivered in order to keep the same FiO2 that was provided in PS (0.4) as controlled by monitor screen (Datex Ohmeda S/5 - Compact Airway Module, M-COVX model, Finland). In this mode, an extensor was employed, one end of which was connected to the oxygen-enriched and the other end was secured to a 3-output ("T") connector, which was attached to the patient's ventilatory prosthesis. During the rest period (30 minutes), patients returned to the mechanical ventilation parameters utilized in the baseline period.

Study Type : Observational
Actual Enrollment : 40 participants
Time Perspective: Cross-Sectional
Official Title: Energy Expenditure During Weaning From Mechanical Ventilation: Is There Any Difference Between Pressure Support and T-Tube?
Study Start Date : March 2006
Actual Primary Completion Date : March 2007
Actual Study Completion Date : March 2008

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with respiratory failure receiving MV fore more than 24 hours, who had been admitted to the Intensive Care Unit (ICU) of the Hospital de Clínicas de Porto Alegre and who met the criteria for weaning from MV according to the parameters previously defined were selected to participate in the study.

Inclusion Criteria:

  • Patients with acute respiratory failure receiving MV for over 24 hours, in the ICU of the Hospital de Clínicas de Porto Alegre

Exclusion Criteria:

  • Patients with chest drainage, hemodynamic instability (characterized by the use of vasoactive drugs), renal failure, mental status change, agitation, sudoresis, tachycardia, axillary temperature above 38°C and inspiratory oxygen fraction (FiO2) over 0.6.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00853060

Federal University of Rio Grande do Sul/Hospital de Clínicas de Porto Alegre
Porto Alegre, RS, Brazil
Sponsors and Collaborators
Hospital de Clinicas de Porto Alegre
Principal Investigator: Silvia Vieira, PhD Federal University of Rio Grande do Sul

Responsible Party: Silvia Regina Rios Vieira, Hospital de Clínicas de Porto Alegre Identifier: NCT00853060     History of Changes
Other Study ID Numbers: 04-415
First Posted: February 27, 2009    Key Record Dates
Last Update Posted: February 27, 2009
Last Verified: February 2009

Keywords provided by Hospital de Clinicas de Porto Alegre:
energy expenditure
mechanical ventilation
pressure support ventilation