Cardiorespiratory Changes in Patients Being Weaned Off Mechanical Ventilation
The objective of this study was to analyze changes in cardiac function using Doppler echocardiogram in critical patients during weaning from mechanical ventilation using two different weaning methods (pressure support and T-tube) and to compare a subgroup of patients: success vs. failure in weaning and patients with vs. without heart disease.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Cardiorespiratory Changes in Patients Being Weaned Off Mechanical Ventilation: a Randomized Crossover Clinical Trial|
|Study Start Date:||December 2005|
|Study Completion Date:||August 2007|
Weaning from mechanical ventilation (MV) involves physiological changes that can overload the cardiorespiratory system due to changes in the interaction between patient and ventilator.
This was a randomized crossover clinical trial that included patients in an intensive care unit (ICU) who had been on MV for more than 48 hours and who were considered ready for weaning. Cardiorespiratory variables, oxygenation, electrocardiogram (ECG) and Doppler echocardiogram findings were analyzed at baseline and after 30 minutes in each trial weaning method (PSV and T-tube). Comparisons were made between PSV and T-tube, weaning success and failure and patients with and without heart disease, using ANOVA and Student's t test. The level of significance was set at p < 0.05.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00852891
|Federal University of Rio Grande do Sul|
|Porto Alegre, RS, Brazil|
|Principal Investigator:||Silvia RR Vieira, PhD||Hospital de Clínicas de Porto Alegre|