Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation.
The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.
|Acute Lung Injury||Other: Intermittent Non-Invasive Ventilation||Phase 1 Phase 2|
|Study Design:||Allocation: Randomized
Masking: Open Label
|Official Title:||A Randomized Clinical Trial on the Use of Early Intermittent Non-Invasive Ventilation in Patients Suffering From Acute Lung Injury After Allogeneic Transplantation|
|Study Start Date:||December 2001|
|Primary Completion Date:||August 2005 (Final data collection date for primary outcome measure)|
No Intervention: Oxygen
Conventional Treatment including Oxygen-support
Conventional Treatment plus intermittent Non-Invasive-Ventilation
|Other: Intermittent Non-Invasive Ventilation|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00852605
|Principal Investigator:||Illmer Thomas, Ph D||Medizinische Klinik I - Universitätsklinikum Carl-Gustav-Carus Dresden|