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Neurohumoral Control of Intestinal Electrical and Mechanical Activity

This study has been completed.
Information provided by (Responsible Party):
Neal Fleming, MD, PhD, University of California, Davis Identifier:
First received: February 26, 2009
Last updated: July 23, 2012
Last verified: July 2012
A collaborative research project with Dr. Kathleen Keef (Department of Physiology, University of Nevada School of Medicine, Reno, Nevada) studying the role of putative neurotransmitters in human intestine.

Morbid Obesity

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Neurohumoral Control of Intestinal Electrical and Mechanical Activity

Further study details as provided by University of California, Davis:

Biospecimen Retention:   Samples Without DNA

Enrollment: 45
Study Start Date: February 2003
Study Completion Date: February 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Detailed Description:
Segments of intestine from patients undergoing elective gastric bypass for morbid obesity or resections for non-obstructive neoplasms at the UC Davis Medical Center will be used. Samples will be taken from tissue normally removed and sent to Pathology or discarded. Full thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either intracellular electrical activity or mechanical contraction. The effects of putative non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. The source of the tissue will not be identified either directly or indirectly through identifiers associated with the measured responses.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients having elective bowel resections

Inclusion Criteria:

  • All patients having elective bowel resection

Exclusion Criteria:

  • Entire resected segment required for pathology
  • Ischemic/necrotic disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00852553

United States, California
University of California, Davis Medical Center
Sacramento, California, United States, 95817
United States, Nevada
University of Nevada School of Medicine
Reno, Nevada, United States, 89557
Sponsors and Collaborators
University of California, Davis
Principal Investigator: Neal W. Fleming, M.D., Ph.D. Professor
  More Information

Responsible Party: Neal Fleming, MD, PhD, Professor, University of California, Davis Identifier: NCT00852553     History of Changes
Other Study ID Numbers: 200311379
Study First Received: February 26, 2009
Last Updated: July 23, 2012

Keywords provided by University of California, Davis:

Additional relevant MeSH terms:
Obesity, Morbid
Nutrition Disorders
Body Weight
Signs and Symptoms processed this record on May 22, 2017