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Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2009 by University Hospital, Strasbourg, France.
Recruitment status was:  Not yet recruiting
Information provided by:
University Hospital, Strasbourg, France Identifier:
First received: February 24, 2009
Last updated: NA
Last verified: February 2009
History: No changes posted
Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures and sometimes with major effects on social, behavioral and cognitive development. Childhood focal epilepsies particularly are age-related diseases mainly occurring during developmental critical period. A complex interplay between brain development and maturation processes and susceptibility genes may contribute to the development of various childhood epileptic syndromes associated with language and cognitive deficits. Indeed, the Landau-Kleffner syndrome (LKS), the continuous spike-and-waves during sleep syndrome (CSWS), and the benign childhood epilepsy with centrotemporal spikes (BCECTS) or benign rolandic epilepsy, are different syndromes that are considered as part of a single continuous spectrum of disorders. While genetic component in those three syndromes remains elusive, novel and high throughput genome analyzes could bring interesting insights into the possible genetic defects and pathophysiological mechanisms underlying and linking the various disorders associating epilepsy with speech and cognitive impairments.

Condition Intervention
Epilepsy Genetic: genome analyzes (genetic defects and pathophysiological mechanisms )

Study Type: Interventional
Official Title: Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits

Resource links provided by NLM:

Further study details as provided by University Hospital, Strasbourg, France:


Ages Eligible for Study:   4 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • iodiopathic focal epilepsy with cognitif deficit

Exclusion Criteria:

  • medical history of status epilepticus
  Contacts and Locations
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Please refer to this study by its identifier: NCT00851331

Contact: Gabrielle Rudolf, PhD, HDR (33) ext 3207

Hôpital Femme Mère Enfant - Hospices Civils de Lyon, Service Epilepsie, Sommeil et Exploration fonctionnelle neurologique pédiatrique Not yet recruiting
Bron, 69500, France
American Memorial Hospital, CHU de Reims, Unité de Neurologie Pédiatrique - Service Pédiatrie A Not yet recruiting
Reims, France, 51092
Clinique neurologique, Hôpitaux Universitaires de Strasbourg Not yet recruiting
Strasbourg, France, 67091
Hôpital de Hautepierre, Service de pédiatrie 1 Not yet recruiting
Strasbourg, France, 67098
Sponsors and Collaborators
University Hospital, Strasbourg, France
Principal Investigator: Edouard HIRSCH, MD University Hospital, Strasbourg, France
  More Information

Responsible Party: Christine GEILLER, Direction de la Recherche Clinique et de l'Innovation - Hôpitaux Universitaires de Strasbourg Identifier: NCT00851331     History of Changes
Other Study ID Numbers: 3391
Study First Received: February 24, 2009
Last Updated: February 24, 2009

Keywords provided by University Hospital, Strasbourg, France:
Benign childhood epilepsy

Additional relevant MeSH terms:
Epilepsies, Partial
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases processed this record on September 20, 2017