Vitamin D Deficiency in Obese Adolescent Girls and Influence of Vitamin D on Insulin Secretion and Sensitivity
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ClinicalTrials.gov Identifier: NCT00850694
Recruitment Status :
First Posted : February 25, 2009
Last Update Posted : April 10, 2017
University of Alabama at Birmingham
Information provided by (Responsible Party):
Ambika Ashraf, M.D., University of Alabama at Birmingham
Sub-clinical vitamin D deficiency is a commonly unrecognized disorder in obese adolescents. The investigators hypothesize vitamin D deficiency will be highly prevalent in obese adolescents and those who are vitamin D deficient will be more insulin resistant.
Condition or disease
Vitamin D DeficiencyObesityInsulin Resistance
This is a cross-sectional study of obese female adolescents matched for age, sex and pubertal staging. Serum 25-OH vitamin D, intact PTH , lipid profile, serum CRP measurements and oral glucose tolerance tests (with glucose and insulin level measurements) will be done to assess the prevalence of vitamin D deficiency and to assess the insulin sensitivity- resistance indices.
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Ages Eligible for Study:
10 Years to 18 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Obese female adolescents
Obese: BMI > 95th percentile
Tanner stage ≥ 4
Children with diabetes, other endocrine or acute or chronic medical illnesses, children on oral contraceptive pills, diuretics and anticonvulsant medications