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Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

This study has been completed.
Vanderbilt University
Information provided by:
Kronos Longevity Research Institute Identifier:
First received: February 17, 2009
Last updated: February 18, 2009
Last verified: February 2009

Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

Condition Intervention
Oxidative Stress Antioxidant Capacity Inflammation Dietary Supplement: Tart Cherry Juice

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women

Further study details as provided by Kronos Longevity Research Institute:

Primary Outcome Measures:
  • plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge.

Secondary Outcome Measures:
  • Urinary markers of oxidative damage.

Enrollment: 12
Study Start Date: October 2007
Study Completion Date: April 2008
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Dietary Supplement: Tart Cherry Juice
    8 fl.oz. twice per day
    Other Name: CherryPharm
Detailed Description:


The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.


Ages Eligible for Study:   55 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • men and women, ages 55-80y, in good health, with >8 years of education
  • non-smoker
  • able to give informed consent

Exclusion Criteria:

  • use of anti-oxidant supplements, in excess of a standard multi-vitamins
  • current hormone replacement therapy
  • any history of significant chronic disease
  • uncontrolled hypertension
  • body mass index (BMI) > 30 kg/m2
  • high physical activity level, as determined by questions on the screening questionnaire
  • use of anti-inflammatory medication
  Contacts and Locations
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Please refer to this study by its identifier: NCT00847743

United States, Arizona
Kronos Longevity Research Institute
Phoenix, Arizona, United States, 85016
Sponsors and Collaborators
Kronos Longevity Research Institute
Vanderbilt University
Principal Investigator: Tinna Traustadottir, Ph.D. Kronos Longevity Research Institute
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Tinna Traustadóttir, Ph.D., Kronos Longevity Research Institute Identifier: NCT00847743     History of Changes
Other Study ID Numbers: KLRI-2007-03
Study First Received: February 17, 2009
Last Updated: February 18, 2009

Keywords provided by Kronos Longevity Research Institute:
oxidative stress

Additional relevant MeSH terms:
Pathologic Processes processed this record on August 23, 2017