Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation
|ClinicalTrials.gov Identifier: NCT00847743|
Recruitment Status : Completed
First Posted : February 19, 2009
Last Update Posted : February 19, 2009
Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.
Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.
We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.
|Condition or disease||Intervention/treatment||Phase|
|Oxidative Stress Antioxidant Capacity Inflammation||Dietary Supplement: Tart Cherry Juice||Not Applicable|
The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women|
|Study Start Date :||October 2007|
|Actual Primary Completion Date :||April 2008|
|Actual Study Completion Date :||April 2008|
Dietary Supplement: Tart Cherry Juice
- plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge.
- Urinary markers of oxidative damage.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00847743
|United States, Arizona|
|Kronos Longevity Research Institute|
|Phoenix, Arizona, United States, 85016|
|Principal Investigator:||Tinna Traustadottir, Ph.D.||Kronos Longevity Research Institute|