Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis.
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The purpose of this study is to compare the bacteria, fungi, and viruses that are present in the sinuses of patients with chronic rhinosinusitis to patients without sinus disease using a new technology, called a microarray, that will allow more accurate identification of microorganisms than current laboratory methods.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Twenty total patients are being recruited: ten adult patients who meet the clinical criteria for chronic rhinosinusitis requiring surgical therapy and ten adult patients undergoing either orbital decompression for Graves' orbitopathy or maxillomandibular advancement for obstructive sleep apnea, with no history of sinus disease.
Age 18 years or older
History of chronic rhinosinusitis (CRS)
Impaired CRS-specific quality of life
Evidence of sinus disease on a CT scan
Control patients with any evidence of CRS by history, survey, or imaging criteria