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Coronary Computed Tomography (CT) Angiography Versus Standard Therapy in the Emergency Room

This study has been completed.
Information provided by (Responsible Party):
Suzanne Chong, MD, University of Michigan Identifier:
First received: February 17, 2009
Last updated: December 4, 2012
Last verified: December 2012

The purpose of this study is to determine the usefulness of CCTA (Coronary Computed Tomography Angiography) in the emergency room setting to diagnose and predict the outcome of patients with chest pain who have a low to moderate risk of heart disease.

And to also determine if the use of CCTA(Coronary Computed Tomography Angiography) is more cost effective (cost less) than the current standards of care treatments. To determine if patients who present to the emergency room w/low to moderate probability of having an ACS (Acute Coronary Syndrome) prefer CCTA (coronary computed tomography angiography)-based care compared to standard algorithm based care.

Condition Intervention
Chest Pain Procedure: CCTA (coronary computed tomography angiography) Other: Control section

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: 64 Slice Coronary CT Angiography vs. Standard Therapy in the Emergency Room: Determining Cost-effectiveness and Predicting Clinical Outcome in Patients With Low and Moderate Risk for Acute Coronary Syndrome.

Resource links provided by NLM:

Further study details as provided by Suzanne Chong, MD, University of Michigan:

Primary Outcome Measures:
  • To assess the usefulness of CCTA (coronary computed tomography angiography)in the emergency room setting to diagnose/predict the outcome of patients w/chest pain who have low to moderate risk of heart disease. [ Time Frame: one year ]

Secondary Outcome Measures:
  • To determine if the use of CCTA (coronary computed tomography angiography)is more cost effective than the current standard of care treatments being used. [ Time Frame: one year ]

Enrollment: 43
Study Start Date: July 2009
Study Completion Date: June 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: chest pain
CCTA (Coronary computed tomography angiography)
Procedure: CCTA (coronary computed tomography angiography)
A CCTA (coronary computed tomography angiography) scan is a CT scan of the blood vessels of the heart. This CCTA (Coronary Computed Tomography Angiography)will be performed and a contrast medication will be injected through an IV line to help make the CT pictures more clear. Medication may or may not be given to control your heart rate during the scan. After the scan is completed it will be read. Your emergency room physician will use the CT results to determine your treatment.
Other: Control section
Normal emergency room treatment for symptoms of chest pain.


Ages Eligible for Study:   25 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 25 years of age or older
  • Experiencing chest pain

Exclusion Criteria:

  • Pregnant
  • At high risk for ACS (Acute Coronary Syndrome)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00846469

United States, Michigan
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48109
Sponsors and Collaborators
University of Michigan
Principal Investigator: Suzanne Chong, MD University of Michigan Hospital
  More Information

Responsible Party: Suzanne Chong, MD, Principal Investigator, University of Michigan Identifier: NCT00846469     History of Changes
Other Study ID Numbers: HUM 0000 7282
Study First Received: February 17, 2009
Last Updated: December 4, 2012

Additional relevant MeSH terms:
Chest Pain
Disease Attributes
Pathologic Processes
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on July 28, 2017