PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration
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|ClinicalTrials.gov Identifier: NCT00846339|
Recruitment Status : Completed
First Posted : February 18, 2009
Last Update Posted : February 23, 2011
|Condition or disease||Intervention/treatment||Phase|
|Smoking||Drug: Bupropion||Phase 4|
Open, one arm, single sequence, 2-period, study stratified into 2 DRD2 genotype groups For subjects who volunteer to cease smoking, genotypes are investigated. Twelve subjects are enrolled (6 - DRD2 Taq1A1 allele, 6 - DRD2 Taq1A2 homozygotes). Subjects receive baseline raclopride PET (High Specific Activity, Low Specific Activity).
- Period 1 Subjects receive 150 mg of bupropion SR every day. After 1 week of medication, pharmacokinetic and PET studies are performed.
- Period 2 Subjects receive 150 mg of bupropion SR twice a day. After 1 week of medication, pharmacokinetic and PET studies are performed.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||[11C] Raclopride PET Imaging Study That Investigates Relation Between Occupancy of Dopamine D2 Receptors and Genotypes of DRD2 After Bupropion Administration|
|Study Start Date :||November 2008|
|Actual Primary Completion Date :||March 2009|
|Actual Study Completion Date :||June 2009|
DRD2 Taq1A1 allele
DRD Taq1 A2 homozygote2
- Dopamine receptor occupancy [ Time Frame: 1 week ]
- Pharmacokinetic parameters of bupropion and hydroxybupropion [ Time Frame: 1 week ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00846339
|Korea, Republic of|
|Seoul National University Hospital|
|Seoul, Korea, Republic of, 110-744|
|Principal Investigator:||Kyung-Sang Yu, MD||Seoul National Univeristy Hospital|