Neuronal Processing of Diacritics: An fMRI Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00845806
Recruitment Status : Completed
First Posted : February 18, 2009
Last Update Posted : November 4, 2011
Information provided by (Responsible Party):
Mitchell Albert, University of Massachusetts, Worcester

Brief Summary:
The purpose of this study is to determine brain function in reading arabic diacritics.

Condition or disease Intervention/treatment
Neuronal Processing of Diacritics Other: MRI

Detailed Description:
fMRI is a well established imaging technique that allows investigators to see regional brain function based off of actions like reading, speaking, playing music, etc. Even the type of language and format of that language can change the area of the brain that is active while performing that action. This study is meant to see the areas of the brain that become active both prior to and during the process of reading diacritic markings in arabic.

Study Type : Observational
Actual Enrollment : 12 participants
Observational Model: Case-Only
Official Title: Neuronal Processing of Diacritics: An fMRI Study
Study Start Date : February 2009
Actual Primary Completion Date : February 2011
Actual Study Completion Date : February 2011

Group/Cohort Intervention/treatment
Arabic Speakers
All subjects must be male native arabic speakers who can read and speak english.
Other: MRI
All subjects will be asked to lay in an MRI for about an hour while reading Arabic diacritic characters
Other Names:
  • Arabic
  • Diacritic
  • fMRI

Primary Outcome Measures :
  1. Observe regional brain function from reading Arabic diacritics [ Time Frame: 1 hour ]

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All subjects will be male native arabic speakers that can read and write english. All will be healthy with no history of neurological or psychiatric disorders.

Inclusion Criteria

Adult patients may be enrolled in this study if they meet the following inclusion criteria:

  • Are male and are 18 years or older, inclusive;
  • Consent from the patient
  • First language is Arabic
  • Must be able to speak and read English
  • Right handed
  • The subject must pass a dyslexia screen test (Attached to consent form).

Exclusion Criteria

Adult patients will be excluded from this study if they do not fulfill the inclusion criteria, or if any of the following conditions have been met:

  • Have any contraindications to an MR exam such as a pace-maker, metallic cardiac valves, magnetic material (i.e., surgical clips) implanted electronic infusion pumps or any other conditions that would preclude proximity to a strong magnetic field;
  • Are undergoing the MR exam in an emergency situation
  • People with psychiatric disorders will be excluded from the study.
  • Are claustrophobic and can not tolerate the imaging.
  • People with neurological diseases
  • Are on any medications for psychiatric, neurological, or chronic pain problems.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00845806

United States, Massachusetts
UMASS Medical School Advanced MRI Center
Worcester, Massachusetts, United States, 01655
Sponsors and Collaborators
University of Massachusetts, Worcester
Principal Investigator: Mitchell S Albert, Ph.D. UMASS Medical School

Responsible Party: Mitchell Albert, Director of Advanced MRI Center, UMASS Medical Sch, University of Massachusetts, Worcester Identifier: NCT00845806     History of Changes
Other Study ID Numbers: Docket # 13127
First Posted: February 18, 2009    Key Record Dates
Last Update Posted: November 4, 2011
Last Verified: November 2011

Keywords provided by Mitchell Albert, University of Massachusetts, Worcester:
Neuronal Processing