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Coronary Flow Reserve and Glucometabolic State

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00845468
Recruitment Status : Completed
First Posted : February 18, 2009
Last Update Posted : February 18, 2009
Information provided by:
Medicinsk Forsknings Afdeling

Brief Summary:

Diabetes mellitus is a major risk factor for the development of ischemic heart disease, and patients with diabetes mellitus have a worse outcome following an acute myocardial infarction than non-diabetic patients. Furthermore, abnormal glucose metabolism below the diagnostic threshold of diabetes mellitus is also associated with increased risk of death compared to patients with a normal glucose metabolism. The frequency of abnormal glucose metabolism in acute myocardial infarction is high, and approximately 70% of myocardial infarction patients have diabetes mellitus, newly diagnosed diabetes mellitus or impaired glucose tolerance, leaving only 30% with normal glucose metabolism. The increased mortality among patients with acute myocardial infarction and abnormal glucose metabolism seems mainly related to a higher occurrence of congestive heart failure, suggesting that an abnormal glucose metabolism may play an important role among others in endothelial dysfunction, infarct healing and overall left ventricle function. This raises the question, whether patients with acute myocardial infarction and abnormal glucose metabolism have increased frequency of micro- or macrovascular disease or both.

Coronary flow velocity reserve reflects the patency of the epicardial coronary artery in combination with vasodilator capacity of the microcirculation and may therefore offer a tool for assessment of macro- and microcirculation.

This study will focus on the relation between coronary flow velocity reserve estimated by transthoracal Doppler echocardiography and mortality, risk for heart failure and left ventricle function after acute myocardial infarction stratified according to glycometabolic state

Condition or disease
Acute Myocardial Infarction Diabetes Mellitus Prediabetes

Study Type : Observational
Actual Enrollment : 190 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Coronary Flow Velocity Reserve According to Glucometabolic State in Acute Myocardial Infarction; Relation to Ventricular Systolic and Diastolic Function
Study Start Date : January 2006
Primary Completion Date : August 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack
U.S. FDA Resources

No treatment

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients suffering from a acute myocardial infarction

Inclusion Criteria:

  1. Newly diagnosed first AMI based on characteristic clinical symptoms and/or electrocardiographic signs of AMI and Troponin T or I or CK-MB over diagnostic limits for AMI
  2. Referral for coronary arteriography based on the actual myocardial infarction
  3. Written informed consent

Exclusion Criteria:

  1. Previous myocardial infarction
  2. Asthma bronchiale
  3. 2 or/and 3 degree atrio-ventricular block and paced rhythm
  4. Mental state that makes the patient unavailable in attending the study
  5. Use of dipyridamol
  6. Sick Sinus Syndrome

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00845468

Hospital of Fünen Svendborg
Svendborg, Denmark, 5700
Sponsors and Collaborators
Medicinsk Forsknings Afdeling
Principal Investigator: Brian B Løgstrup, MD Medicinsk Forsknings Afdeling

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Brian Bridal Løgstrup, Medicinsk Forskning Afdeling Identifier: NCT00845468     History of Changes
Other Study ID Numbers: 07-4-B368-A1392-22379
VF 20050103
First Posted: February 18, 2009    Key Record Dates
Last Update Posted: February 18, 2009
Last Verified: February 2009

Keywords provided by Medicinsk Forsknings Afdeling:
coronary flow reserve
diabetes mellitus
acute myocardial infarction
transthoracic echocardiography

Additional relevant MeSH terms:
Diabetes Mellitus
Myocardial Infarction
Prediabetic State
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases