Racial Differences in Orthostatic Tolerance

This study has been completed.
Information provided by:
Yale University
ClinicalTrials.gov Identifier:
First received: February 13, 2009
Last updated: NA
Last verified: February 2009
History: No changes posted

Our central hypothesis is that baroreflex sensitivity is attenuated in black women compared to white women, and that this dysregulation will be apparent during orthostatic challenges. We expect that the cumulative stress index (CSI), a measure of maximal orthostatic tolerance, is higher in Black women (BW) compared to White women (WW).

Orthostatic Tolerance

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Racial Differences in Orthostatic Tolerance

Further study details as provided by Yale University:

Primary Outcome Measures:
  • orthostatic tolerance [ Time Frame: 1 ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

whole blood

Enrollment: 18
Study Start Date: October 2007
Study Completion Date: January 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
white women
Black women


Ages Eligible for Study:   18 Years to 25 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Community sample of women of reproductive age


Inclusion Criteria:

  • women between 18-25 yrs of age

Exclusion Criteria:

  • history of high blood pressure, uterine fibroids, diabetes, epilepsy
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00844181

United States, Connecticut
John B. Pierce Laboratory
New Haven, Connecticut, United States, 06519
Sponsors and Collaborators
Yale University
Principal Investigator: Nina Stachenfeld, PhD Yale University
  More Information

No publications provided

Responsible Party: Nina Stachenfeld, PhD, John B. Pierce Laboratory
ClinicalTrials.gov Identifier: NCT00844181     History of Changes
Other Study ID Numbers: 0512000875, 3 R01 HL071159-04A1S1
Study First Received: February 13, 2009
Last Updated: February 13, 2009
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on October 09, 2015