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Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating

This study has been completed.
GE Healthcare
Information provided by (Responsible Party):
M.D. Anderson Cancer Center Identifier:
First received: February 12, 2009
Last updated: February 15, 2016
Last verified: January 2012


Evaluation of an amplitude based gated Positron Emission Tomography (PET) data acquisition system for all GE Discovery Positron Emission Tomography/ Computed Tomography (PET/CT) scanners.

Condition Intervention
Lung Cancer Procedure: PET/CT Scan

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating

Resource links provided by NLM:

Further study details as provided by M.D. Anderson Cancer Center:

Primary Outcome Measures:
  • Mean Difference Between Gated + Ungated PET/CT Scans [ Time Frame: Scheduled PET/CT scans extended by 10 minutes ]

Enrollment: 12
Study Start Date: March 2009
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
PET/CT Scan Procedure: PET/CT Scan
PET/CT scan performed with elastic belt around lower chest/upper abdomen to track breathing motion.
Other Names:
  • Positron Emission Tomography
  • Positron Emission Tomography/Computed Tomography
  • Computed Tomography

Detailed Description:

Routine PET/CT scans are taken while patients are breathing normally. The motions made by breathing can reduce the image quality of the scan. Minimizing the effects of this motion by taking the images and processing the scans differently may improve the image quality.

The PET/CT Scan:

If you agree to take part in this study, an elastic belt will be placed around your lower chest/upper abdomen before your routine PET/CT scan. This belt is used to track your breathing motion. This information will be used to help process the scan.

Your PET/CT scan will be performed as usual. During the scan, researchers will focus on your lower chest/upper abdomen (areas that experience breathing motion). Having to focus on this area might extend the scan by up to 10 minutes.

The additional scan time will not increase your radiation exposure since only PET scanning will be performed.

Length of Study:

Your participation on this study will be complete when your scheduled PET/CT scan is complete.

This is an investigational study. The imaging focused on your lower chest/upper abdomen during the scan is investigational.

Up to 26 patients will take part in this study. All will be enrolled at M. D. Anderson.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Individuals over the age of 18 with non-small cell lung cancer (NSCLC) and are scheduled to have a positron emission tomography/computed tomography (PET/CT) scan.

Inclusion Criteria:

  1. Patients with lung or liver lesions measuring 0.5-2cm in diameter will be considered.
  2. Patients that are scheduled to be imaged in the PET/CT suite at the Mays Building will only be considered.

Exclusion Criteria:

  1. Pediatric patients (younger than 18 years) will be excluded.
  2. Patients that cannot tolerate being scanned for an additional 10 minutes with arms above their head will be excluded.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00843219

United States, Texas
UT MD Anderson Cancer Center
Houston, Texas, United States, 77030
Sponsors and Collaborators
M.D. Anderson Cancer Center
GE Healthcare
Principal Investigator: Osama R Mawlawi, PHD UT MD Anderson Cancer Center
  More Information

Additional Information:
Responsible Party: M.D. Anderson Cancer Center Identifier: NCT00843219     History of Changes
Other Study ID Numbers: 2008-0851
Study First Received: February 12, 2009
Last Updated: February 15, 2016

Keywords provided by M.D. Anderson Cancer Center:
Lung Cancer
Non-small cell Lung Cancer
Motion Correction
Positron Emission Tomography
Computed Tomography
Amplitude Gating

Additional relevant MeSH terms:
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases processed this record on August 21, 2017