Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia (RASPALL)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2009 by Hospital Universitari Joan XXIII de Tarragona..
Recruitment status was  Recruiting
Information provided by:
Hospital Universitari Joan XXIII de Tarragona.
ClinicalTrials.gov Identifier:
First received: February 11, 2009
Last updated: NA
Last verified: February 2009
History: No changes posted
Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection.The possible association between oral care and incidence of VAP, and the role of dental plaque, mouth and tracheal colonization have not been firmly established. The investigators' hypothesis was that improving oral care with electrical toothbrushing might be effective in reducing the incidence of VAP.

Condition Intervention Phase
Ventilator-Associated Pneumonia
Nosocomial Pneumonia
Procedure: Toothbrushing
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Prevention
Official Title: Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia

Resource links provided by NLM:

Further study details as provided by Hospital Universitari Joan XXIII de Tarragona.:

Primary Outcome Measures:
  • Ventilator-Associated Pneumonia (VAP) [ Time Frame: 28 days ] [ Designated as safety issue: No ]

Estimated Enrollment: 400
Study Start Date: May 2005
Arms Assigned Interventions
Experimental: Raspall Procedure: Toothbrushing
No Intervention: Control


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adult intubated patients
  • Without evidence of pulmonary infection (randomized within 12h of intubation if they were expected to remain ventilated for longer than 48 hours)

Exclusion Criteria:

  • Absence of dental pieces
  • Current diagnosis of pneumonia or massive bronchoaspiration
  • Tracheostomy (or expected within 48 hours)
  • Chlorhexidine allergy
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00842478

Contact: Angel Pobo, MD 34 977 295818 angel.pobo@gmail.com

ICU, Hospital Universitari Joan XXIII Recruiting
Tarragona, Spain, 43005
Contact: Angel Pobo, MD    34 977295818    angel.pobo@gmail.com   
Sub-Investigator: Angel Pobo, MD         
Principal Investigator: Jordi Rello, MD, PhD         
Sponsors and Collaborators
Hospital Universitari Joan XXIII de Tarragona.
Principal Investigator: Jordi Rello, MD, PhD Hospital Universitari Joan XXIII
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jordi Rello, Hospital Universitari Joan XXIII
ClinicalTrials.gov Identifier: NCT00842478     History of Changes
Other Study ID Numbers: FIS 06/0060 
Study First Received: February 11, 2009
Last Updated: February 11, 2009
Health Authority: Spain: Comité Ético de Investigación Clínica

Additional relevant MeSH terms:
Pneumonia, Ventilator-Associated
Cross Infection
Lung Diseases
Lung Injury
Respiratory Tract Diseases
Respiratory Tract Infections
Ventilator-Induced Lung Injury

ClinicalTrials.gov processed this record on May 26, 2016