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Investigating the Role of the Premotor Cortex in Higher Cognitive Functions

This study has been terminated.
(not enough enrollment)
Information provided by:
Assistance Publique - Hôpitaux de Paris Identifier:
First received: February 11, 2009
Last updated: NA
Last verified: November 2008
History: No changes posted
This project aims at understanding better the role of the frontal lobe of the brain in our capacity to perceive visual information consciously, and also, in our capacity to perceive others' actions. It includes a test where we ask subjects to detect visual information in front of a computer screen, and another test where we ask them to imitate finger movements.

Brain Injury Chronic

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: What Part Does the Premotor Cortex Play in Subjective Visual Perception and in the Perception of Others' Actions?

Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Enrollment: 9
Study Start Date: May 2007
Study Completion Date: September 2007
Primary Completion Date: September 2007 (Final data collection date for primary outcome measure)
The study compares brain-damaged patients with healthy ones on two psychophysical tasks.
The study does not intervene on the brain-damaged patients, it merely compares their behaviour with that of healthy patients on a range of psychophysical tasks.

Detailed Description:
This project is a twofold exploration of the functions of the premotor cortex, concerning, on the one hand, its role in conscious visual perception, and on the other hand, the part it may play in the perception and imitation of other people's movements. Healthy subjects will be compared with subjects suffering from focal lesions within the premotor cortex, on two tasks: in the first task, the subjects will have to make a decision concerning the absence or presence of a visual item in their field of vision. They will make (virtual) bets based on the subjective certainty of their perceptions - they will be told that these bets are purely virtual, and will not result in any financial gain or loss. This study will help us understand the contribution of the prefrontal cortex to subjective weighing of perceptual certainty. In the second task, the subjects will imitate a finger movement, based either on a fixed picture, or on a short motion picture. Previous studies have shown that whether the movement is copied from a fixed picture or a moving picture changes reaction times and types of mistakes. Neuroimaging studies have shown that a premotor area is involved in this effect. The comparison of brain-damaged and healthy subjects will tell us what exactly the contribution of the prefrontal consists in.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The visual pereption of subjects willl be studied, but no attempt will be made at modifying it, or treating any problem that they might have.

Inclusion Criteria:

  • Healthy subjects chosen from a pool of adult subjects, recruited through ads.
  • In the second group, the subjects are recruited from a pool of brain-damaged patients treated at the hospital de la Pitié-Salpétrière. They must suffer from a focal lesion in the prefrontal cortex.

Exclusion Criteria:

  • For the healthy group: any previous brain-related medical history.
  • Widespread brain-damage, extending beyond the prefrontal cortex, that is to say, lesions that are not really focal.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00842413

Hôpital de la Pitié-Salpétrière
Paris, France, 75013
Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
Principal Investigator: Richard Levy, MD Assistance Publique - Hôpitaux de Paris
  More Information

Responsible Party: Yannick Vacher, Clinical Research Department of Developpement Identifier: NCT00842413     History of Changes
Other Study ID Numbers: P060605
Study First Received: February 11, 2009
Last Updated: February 11, 2009

Keywords provided by Assistance Publique - Hôpitaux de Paris:
Prefrontal cortex
visual consciousness
focal lesions
action perception

Additional relevant MeSH terms:
Brain Injuries
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries processed this record on July 21, 2017