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Markers of Airway Inflammation in BAL Fluid From Children With Asthma

This study is enrolling participants by invitation only.
Genentech, Inc.
Information provided by (Responsible Party):
Jennifer Brandorff, National Jewish Health Identifier:
First received: February 4, 2009
Last updated: December 5, 2016
Last verified: December 2016
The study compares the biochemical markers in bronchoalveolar lavage samples from asthmatic children to those markers found in non-asthmatic children with other respiratory diseases. The investigators hypothesize that certain markers will be associated specifically with asthma.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Prospective Analysis of Markers of Airway Inflammation and Remodeling in Bronchoalveolar Lavage Fluid From Children With Asthma.

Further study details as provided by National Jewish Health:

Primary Outcome Measures:
  • The measurement of levels of lipopolysaccharides [LPS], which mediates airway inflammation, in bronchoalveolar lavage [BAL] fluid from children with asthma and comparison to LPS levels in children with non-asthma respiratory diseases [ Time Frame: Single time point ]

Secondary Outcome Measures:
  • Characterization of the inflammatory cytokine and chemokine profiles in bronchoalveolar lavage [BAL] fluid in children with asthma and comparison to the profile for children with non-asthma respiratory diseases. [ Time Frame: Single time point ]

Estimated Enrollment: 40
Study Start Date: October 2007
Estimated Study Completion Date: January 2021
Estimated Primary Completion Date: October 2020 (Final data collection date for primary outcome measure)
1 Asthma subjects
Children with asthma undergoing clinically indicated bronchoscopy at National Jewish Health.
2 Non-asthma subjects
Children with other respiratory diseases than asthma undergoing clinically indicated bronchoscopy at National Jewish Health.


Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients undergoing bronchoscopy at National Jewish Health

Inclusion Criteria:

  • 18 years of age or younger
  • Scheduled for bronchoscopy at National Jewish Health for persistent asthma, persistent, poorly controlled wheezing, chronic cough, GERD, atelectasis, bronchopulmonary dysplasia, infection.
  • Consent and assent from parent and patient [if appropriate].

Exclusion Criteria:

  • Unwillingness to consent/assent to retrieval of BAL fluid for research analysis.
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Please refer to this study by its identifier: NCT00838552

United States, Colorado
National Jewish Health
Denver, Colorado, United States, 80206
Sponsors and Collaborators
National Jewish Health
Genentech, Inc.
Principal Investigator: Pia Hauk, MD National Jewish Health
  More Information

Responsible Party: Jennifer Brandorff, Regulatory Manager, National Jewish Health Identifier: NCT00838552     History of Changes
Other Study ID Numbers: NJ HS-2178
Study First Received: February 4, 2009
Last Updated: December 5, 2016

Keywords provided by National Jewish Health:
asthma inflammation bronchoscopy

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Pathologic Processes processed this record on April 26, 2017