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Stromal Gene Expression During Pulmonary Sarcoidosis

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ClinicalTrials.gov Identifier: NCT00837668
Recruitment Status : Terminated (Interim analysis)
First Posted : February 5, 2009
Last Update Posted : June 14, 2017
Sponsor:
Information provided by (Responsible Party):
Elliott Crouser MD, Ohio State University

Brief Summary:
to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis. By so doing, we hope to identify unique genetic mechanisms which will aid in the diagnosis of sarcoidosis and will help us understand the pathogenesis of this poorly understood disease.

Condition or disease
Sarcoidosis

Detailed Description:
to collect small sample of lung tissue recovered from a clinical procedure such as bronchoscopy, or a mediastinoscopy (a procedure in which a lighted instrument (mediastinoscope) is inserted through a neck incision to visually examine the structures in the top of the chest cavity and to take a sample (biopsy) of tissue.

Study Type : Observational
Estimated Enrollment : 110 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Stromal Gene Expression During Pulmonary Sarcoidosis
Study Start Date : April 2005
Primary Completion Date : February 2012
Study Completion Date : February 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort
sarcoidosis
sarcoidosis patients undergoing clinical bronchoscopy



Primary Outcome Measures :
  1. To Identify Gene Expression Patterns That Specifically Correlate With Active Pulmonary Sarcoidosis. [ Time Frame: end of study ]

Secondary Outcome Measures :
  1. To Determine if Gene Expression Patterns Correlate With The Severity of Illness Of Sarcoidosis Patients [ Time Frame: end of study ]

Biospecimen Retention:   Samples With DNA
lung tissue


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients from sarcoidosis clinic
Criteria

Inclusion Criteria:

  • diagnosis of sarcoidosis

Exclusion Criteria:

  • inability to provide consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00837668


Locations
United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
Investigators
Principal Investigator: Elliott Crouser, MD Ohio State University

Responsible Party: Elliott Crouser MD, Associate Professor of Internal Medicine, Ohio State University
ClinicalTrials.gov Identifier: NCT00837668     History of Changes
Other Study ID Numbers: 2005H0018
First Posted: February 5, 2009    Key Record Dates
Last Update Posted: June 14, 2017
Last Verified: June 2017

Keywords provided by Elliott Crouser MD, Ohio State University:
sarcoidosis
stromal gene expression
pulmonary sarcoidosis
bronchoscopy

Additional relevant MeSH terms:
Sarcoidosis
Sarcoidosis, Pulmonary
Lymphoproliferative Disorders
Lymphatic Diseases
Lung Diseases, Interstitial
Lung Diseases
Respiratory Tract Diseases