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Stromal Gene Expression During Pulmonary Sarcoidosis

This study has been terminated.
(Interim analysis)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00837668
First Posted: February 5, 2009
Last Update Posted: June 14, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Elliott Crouser MD, Ohio State University
  Purpose
to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis. By so doing, we hope to identify unique genetic mechanisms which will aid in the diagnosis of sarcoidosis and will help us understand the pathogenesis of this poorly understood disease.

Condition
Sarcoidosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Stromal Gene Expression During Pulmonary Sarcoidosis

Resource links provided by NLM:


Further study details as provided by Elliott Crouser MD, Ohio State University:

Primary Outcome Measures:
  • To Identify Gene Expression Patterns That Specifically Correlate With Active Pulmonary Sarcoidosis. [ Time Frame: end of study ]

Secondary Outcome Measures:
  • To Determine if Gene Expression Patterns Correlate With The Severity of Illness Of Sarcoidosis Patients [ Time Frame: end of study ]

Biospecimen Retention:   Samples With DNA
lung tissue

Estimated Enrollment: 110
Study Start Date: April 2005
Study Completion Date: February 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
sarcoidosis
sarcoidosis patients undergoing clinical bronchoscopy

Detailed Description:
to collect small sample of lung tissue recovered from a clinical procedure such as bronchoscopy, or a mediastinoscopy (a procedure in which a lighted instrument (mediastinoscope) is inserted through a neck incision to visually examine the structures in the top of the chest cavity and to take a sample (biopsy) of tissue.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients from sarcoidosis clinic
Criteria

Inclusion Criteria:

  • diagnosis of sarcoidosis

Exclusion Criteria:

  • inability to provide consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00837668


Locations
United States, Ohio
The Ohio State University
Columbus, Ohio, United States, 43210
Sponsors and Collaborators
Ohio State University
Investigators
Principal Investigator: Elliott Crouser, MD Ohio State University
  More Information

Responsible Party: Elliott Crouser MD, Associate Professor of Internal Medicine, Ohio State University
ClinicalTrials.gov Identifier: NCT00837668     History of Changes
Other Study ID Numbers: 2005H0018
First Submitted: February 4, 2009
First Posted: February 5, 2009
Last Update Posted: June 14, 2017
Last Verified: June 2017

Keywords provided by Elliott Crouser MD, Ohio State University:
sarcoidosis
stromal gene expression
pulmonary sarcoidosis
bronchoscopy

Additional relevant MeSH terms:
Sarcoidosis
Sarcoidosis, Pulmonary
Lymphoproliferative Disorders
Lymphatic Diseases
Lung Diseases, Interstitial
Lung Diseases
Respiratory Tract Diseases