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Vascular Dysfunction in Offspring of Assisted Reproduction Technologies

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2009 by University of Lausanne Hospitals.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00837642
First Posted: February 5, 2009
Last Update Posted: February 5, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Lausanne Hospitals
  Purpose

The prevalence of infertility has been estimated at 9% worldwide. The steadily increasing use of assisted reproductive technologies (ART) has allowed millions of infertile couples to have children. These children make up for 1 to 4% of the population in developed countries. ART involves the manipulation of early embryos at a time when they may be particularly vulnerable to external disturbances. In line with this concept, studies in mice suggest that ART alters the activity of enzymes involved in the regulation of metabolic and cardiovascular homeostasis. Alternatively, infertility itself or the drugs used to stimulate ovulation may have adverse effects on the outcome of the offspring. The safety of ART for long-term health is, therefore, of utmost importance. Among the potential long-term consequences of ART, cardiovascular disease may represent an important candidate, but there is no information.

Preliminary data from our group show that, children born after in vitro fertilization (IVF) present systemic and pulmonary vascular dysfunction at high-altitude when compared to age- and sex-matched control subjects.

Therefore, the major goal of our proposal is to test the hypothesis that apparently healthy children born after ART display vascular dysfunction of both the pulmonary and the systemic circulation.


Condition Intervention
Infertility Dietary Supplement: Vitamin C and E

Study Type: Interventional
Official Title: Vascular Dysfunction in Offspring of Assisted Reproduction Technologies

Resource links provided by NLM:


Further study details as provided by University of Lausanne Hospitals:

Primary Outcome Measures:
  • Endothelial function

Study Start Date: March 2008
Estimated Study Completion Date: December 2009
Estimated Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   10 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Offspring of ART
  • Healthy
  • No medication
  • Born at term

Exclusion Criteria:

  • Cardio-pulmonary malformations
  • Neuro-muscular malformations
  • Previous high altitude diseases
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00837642


Contacts
Contact: Urs Scherrer, Prof +4121 314 09 30 Urs.Scherrer@chuv.ch
Contact: Claudio Sartori, Prof +4121 314 09 30 Claudio.Sartori@chuv.ch

Locations
Switzerland
University Hospital Recruiting
Bern, BE, Switzerland, 3000
Contact: Yves Allemann, Prof       Yves.Allemann@insel.ch   
University Hospital Recruiting
Lausanne, VD, Switzerland, 1011
Contact: Urs Scherrer, Prof    +4121 314 09 30    Urs.Scherrer@chuv.ch   
Sponsors and Collaborators
University of Lausanne Hospitals
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof Urs Scherrer, University Hospital Lausanne
ClinicalTrials.gov Identifier: NCT00837642     History of Changes
Other Study ID Numbers: 35/07
First Submitted: February 4, 2009
First Posted: February 5, 2009
Last Update Posted: February 5, 2009
Last Verified: January 2009

Keywords provided by University of Lausanne Hospitals:
Vascular function in offspring of ART

Additional relevant MeSH terms:
Infertility
Genital Diseases, Male
Genital Diseases, Female