Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact (SNA&Sepsis)
Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Autonomic Nervous System Alteration Induce by Sepsis:Assessment and Prognosis Impact|
- Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission [ Time Frame: 48 hours post admission ] [ Designated as safety issue: No ]
- plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation [ Time Frame: 30 days ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Peptid and protein sAmple
|Study Start Date:||October 2008|
|Study Completion Date:||September 2011|
|Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
Our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of MIBG.
The second aim is 1)to assess links between alteration of cardiac sympathic nervous system and NT-PRoBNP variations in sepsis and 2)To know prognostic impact in sympathic nervous system compare to NTproBNP.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00835913
|University Hospital Grenoble|
|Grenoble, France, 38000|
|Principal Investigator:||SCHWEBEL Carole, PH||Unit intensive care|