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Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact (SNA&Sepsis)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Grenoble Identifier:
First received: February 3, 2009
Last updated: January 16, 2015
Last verified: July 2010
Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.

Condition Phase
Septic Shock Severe Sepsis Phase 4

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Autonomic Nervous System Alteration Induce by Sepsis:Assessment and Prognosis Impact

Resource links provided by NLM:

Further study details as provided by University Hospital, Grenoble:

Primary Outcome Measures:
  • Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission [ Time Frame: 48 hours post admission ]

Secondary Outcome Measures:
  • plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation [ Time Frame: 30 days ]

Biospecimen Retention:   Samples Without DNA
Peptid and protein sAmple

Enrollment: 13
Study Start Date: October 2008
Study Completion Date: September 2011
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Detailed Description:

Our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of MIBG.

The second aim is 1)to assess links between alteration of cardiac sympathic nervous system and NT-PRoBNP variations in sepsis and 2)To know prognostic impact in sympathic nervous system compare to NTproBNP.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
All patient transfer in intensive care unit with sepsis chock or severe sepsis define as Bone criteria.

Inclusion Criteria:

  • Patient over 18 years admitted in intensive care unit and having severe sepsis criteria or septic shock documented or suspected define as Bone Criteria
  • hemodynamically stable situation
  • sinusal rhythm
  • Patient for social security

Exclusion Criteria:

  • Minors
  • Patient under guardianship or trusteeship
  • pregnant or lactating women
  • diabetic
  • cardiomyopathy known and/or treated or detect in admission
  • electro-systolic process permanent or transitory
  • neurological history or degenerative pathology
  • chronic respiratory insufficiency
  • Chronic renal insufficiency
  Contacts and Locations
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Please refer to this study by its identifier: NCT00835913

University Hospital Grenoble
Grenoble, France, 38000
Sponsors and Collaborators
University Hospital, Grenoble
Principal Investigator: SCHWEBEL Carole, PH Unit intensive care
  More Information

Responsible Party: University Hospital, Grenoble Identifier: NCT00835913     History of Changes
Other Study ID Numbers: 06PHR04
Study First Received: February 3, 2009
Last Updated: January 16, 2015

Keywords provided by University Hospital, Grenoble:
Autonomic nervous system
Sepsis shock
severe sepsis
sinusal change
Myocardiac fixing
Patient in intensive care unit with sepsis shock or severe

Additional relevant MeSH terms:
Shock, Septic
Systemic Inflammatory Response Syndrome
Pathologic Processes
Shock processed this record on September 19, 2017