Safety and Efficacy of L-NAME and Midodrine to Increase MAP
|ClinicalTrials.gov Identifier: NCT00835224|
Recruitment Status : Completed
First Posted : February 3, 2009
Results First Posted : April 23, 2014
Last Update Posted : April 23, 2014
|Condition or disease||Intervention/treatment||Phase|
|Orthostatic Hypotension Spinal Cord Injury||Drug: L-NAME Drug: Midodrine Drug: Placebo||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||34 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia|
|Study Start Date :||May 2010|
|Primary Completion Date :||June 2013|
|Study Completion Date :||August 2013|
A drug to treat low blood pressure.
To treat low blood pressure.
L-Name: A non-selective inhibitor of nitric oxide synthase and placebo. It has been used experimentally to induce hypertension.
A non-selective inhibitor of nitric oxide synthase and placebo. It has been used experimentally to induce hypertension.
Placebo Comparator: Placebo
Placebo: A pill with an inactive substance that looks like the study drug.
A pill with an inactive substance that looks like the study drug.
- Blood Pressure [ Time Frame: Blood pressure during the 4 hour period after no drug, L-NAME (IV: 1.0 mg/kg) and midodrine (PO: 10.0 mg) administration ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00835224
|United States, New York|
|VA Medical Center, Bronx|
|Bronx, New York, United States, 10468|
|Principal Investigator:||Jill Wecht, EdD||VA Medical Center, Bronx|