Collecting Blood and Tissue Samples From Family Members of Patients With Pancreatic Diseases, Pancreatic Cancer, and Melanoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT00835133
Recruitment Status : Recruiting
First Posted : February 3, 2009
Last Update Posted : September 11, 2017
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Gloria M. Petersen, Mayo Clinic

Brief Summary:

RATIONALE: Collecting and storing samples of blood and tissue from family members of patients with cancer to test in the laboratory may help the study of cancer in the future.

PURPOSE: This clinical trial is collecting blood and tissue samples from family members of patients with pancreatic disease, pancreatic cancer, and melanoma.

Condition or disease Intervention/treatment
Familial Pancreatic Cancer Other: biologic sample preservation procedure Other: medical chart review Other: survey administration

Detailed Description:


  • To collect clinical history, family history, and blood and/or tissue samples from family members of patients diagnosed with pancreatic diseases, pancreatic cancer, or melanoma.
  • To learn whether inherited factors increase the risk of pancreatic diseases, pancreatic cancer, or other cancers.

OUTLINE: Study participants undergo collection of blood and/or tissue samples as well as survey data for inclusion in a familial data and tissue registry. Participants complete two baseline surveys regarding their personal, family, health, and environmental exposure histories and regarding their opinions on cancer and cancer screening. Patients also complete a follow-up survey at 1 year and undergo review of their medical records.

Study Type : Observational
Estimated Enrollment : 4000 participants
Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Biospecimen Resource for Familial Pancreas Research, a Data and Tissue Registry (Also Known as a Bio-repository, Bio-bank, Data and Tissue Database, Data and Tissue Bank, Etc.) to Help Advance Research in Familial Pancreas Disease
Study Start Date : August 2002
Estimated Primary Completion Date : September 2022
Estimated Study Completion Date : September 2022

Resource links provided by the National Library of Medicine

Intervention Details:
  • Other: biologic sample preservation procedure
    one blood sample or saliva sample collection
  • Other: medical chart review
    confirmation of cancer diagnosis
  • Other: survey administration
    at baseline enrollment and 12 months post-enrollment

Primary Outcome Measures :
  1. Collection of familial data and biospecimens in a data and tissue repository for familial pancreas research [ Time Frame: baseline ]

Biospecimen Retention:   Samples With DNA
Two 10mL plasma tubes and two 10mL serum tubes collected. DNA extracted from blood lymphocytes. Possible saliva sample for DNA extraction. Waste tissue from previous surgery may be requested.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 120 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Familial pancreatic cancer kindred


  • Meets 1 of the following criteria:

    • Has at least 2 blood relatives with pancreatic cancer (both must be related)
    • Has at least 1 blood relative with pancreatic cancer and 1 with melanoma (both must be related)


  • Mentally competent and able to provide informed consent
  • Able to understand and read English


  • Not specified

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00835133

Contact: Bridget Eversman 1-800-914-7962
Contact: Sarah Amundson 1-800-914-7962

United States, Minnesota
Mayo Clinic Cancer Center Recruiting
Rochester, Minnesota, United States, 55905
Contact: Clinical Trials Office - All Mayo Clinic Locations    507-538-7623      
Sponsors and Collaborators
Mayo Clinic
National Cancer Institute (NCI)
Principal Investigator: Gloria M. Petersen, PhD, FACMG Mayo Clinic

Responsible Party: Gloria M. Petersen, PhD, Mayo Clinic Identifier: NCT00835133     History of Changes
Other Study ID Numbers: 355-06
R01CA097075-08 ( U.S. NIH Grant/Contract )
CDR0000613097 ( Registry Identifier: NCI )
First Posted: February 3, 2009    Key Record Dates
Last Update Posted: September 11, 2017
Last Verified: September 2017

Keywords provided by Gloria M. Petersen, Mayo Clinic:

Additional relevant MeSH terms:
Pancreatic Diseases
Pancreatic Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Endocrine Gland Neoplasms
Digestive System Diseases
Endocrine System Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Gastrointestinal Agents