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Phase Out in Tinnitus Patients

This study has been completed.
Information provided by:
University Hospital, Antwerp Identifier:
First received: January 30, 2009
Last updated: March 2, 2009
Last verified: December 2008

Phase shift treatment is a new tinnitus therapy that aims at sound cancelling via complete or partial residual inhibition. This technique is based on the theory by Choy advocating that the induction of a sound wave with a 180 degree phase shift compared to the sound experienced by the patient could result in sound cancelling, likely by negation of the cortical perception of tinnitus.

The aim is to determine the efficacy of the Phase Out treatment in pure tone and narrow band noise tinnitus patients.

Condition Intervention Phase
Tinnitus Device: Phase Out treatment in pure tone tinnitus patients Phase 4

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase Out Treatment for Tinnitus

Resource links provided by NLM:

Further study details as provided by University Hospital, Antwerp:

Primary Outcome Measures:
  • Visual Analogue Scale [ Time Frame: 3x/week ]

Secondary Outcome Measures:
  • Score on Tinnitus Questionnaire [ Time Frame: week 0, week 3, week 6 ]

Estimated Enrollment: 40
Study Start Date: March 2008
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: narrow band noise
Phase out in narrow band noise tinnitus patients
Device: Phase Out treatment in pure tone tinnitus patients
Phase Out treatment: 30 min 3x/w during 6 weeks


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • consult ENT department UZA with tinnitus
  • pure tone tinnitus or narrow band noise tinnitus
  • unilateral tinnitus, or bilateral tinnitus if both ears pure tone or both ears narrow band noise
  • frequency tinnitus > 1kHz
  • cochlear origin tinnitus
  • tinnitus duration 3 months or longer
  • age 18y or more
  • patient being able to cooperate
  • patiënt able to fill in VAS
  • normal MRI pontine angle

Exclusion Criteria:

  • depression: BDI > 21
  • pulsatile tinnitus
  • pregnancy
  • epilepsy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00833950

Antwerp university Hospital
Edegem, Antwerp, Belgium, 2650
Sponsors and Collaborators
University Hospital, Antwerp
  More Information

Responsible Party: Prof Dr P H Van de Heyning, Antwerp University Hospital Identifier: NCT00833950     History of Changes
Other Study ID Numbers: 8/2/12
Study First Received: January 30, 2009
Last Updated: March 2, 2009

Keywords provided by University Hospital, Antwerp:
Phase Out

Additional relevant MeSH terms:
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on August 22, 2017