Neuroendocrine Mechanisms of Growth and Body Composition in Preterm and Term Infants (PREMA)
The purpose of this study is to test the feasibility of measuring body composition by air displacement plethysmography (ADP) in rapidly growing, medically stable late gestation [32-35 weeks post-menstrual age (PMA)] premature infants.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Neuroendocrine Mechanisms of Growth and Body Composition in Preterm and Term Infants|
- Growth trajectory [ Time Frame: Weekly ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||January 2008|
|Study Completion Date:||June 2012|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
Full Term Infants
Infants born between 37 4/7 weeks and 42 3/7 weeks gestation.
Infants born between 32 4/7 weeks and 35 3/7 weeks gestation.
- To assess the feasibility of measuring body fat deposition by ADP in medically stable late gestation (32-35 weeks), premature infants during a period of rapid postnatal growth.
- To test the relationship between %BF by ADP to %BF by DXA, as well as characterize the relationship between these fat measures with bone measures by quantitative ultrasound and serum levels of insulin, IGF-1, IGF binding proteins, adiponectin and leptin.
- To perform inter- and intra-rater testing of anthropometric, ultrasound, and ADP measurements.
- Compare growth, body composition and bone strength between infants born preterm to infants born full term.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00833222
|United States, Utah|
|University of Utah|
|Salt Lake City, Utah, United States, 84132|
|Principal Investigator:||Laurie Moyer-Mileur, PhD||University of Utah|
|Principal Investigator:||Kristine Jordan, MPH, PhD||University of Utah|