Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis
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|ClinicalTrials.gov Identifier: NCT00833157|
Recruitment Status : Unknown
Verified January 2009 by Bispebjerg Hospital.
Recruitment status was: Active, not recruiting
First Posted : January 30, 2009
Last Update Posted : January 30, 2009
The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.
The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.
|Condition or disease||Intervention/treatment||Phase|
|Osteoarthritis of the Knee||Drug: glucosamine sulphate Drug: ibuprofen Drug: placebo||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||36 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis|
|Study Start Date :||February 2005|
|Actual Primary Completion Date :||July 2007|
|Estimated Study Completion Date :||March 2009|
Drug: glucosamine sulphate
Subjects are administered glucosamine-sulphate tablets of 500 mg * 3 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks.
Other Name: glucosamine from Ferrosan
Subjects are administered 600 mg * 2 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks
Other Name: "Ibumetin" from Nycomed (vnr:38 83 71)
|Placebo Comparator: Placebo||
Subjects are administered placebo tablets, while they are performing a strength-training program (*3 weekly) with both legs for 12 weeks
- muscle strength and hypertrophy [ Time Frame: We measure before and after 12-weeks strength training. ]
- cartilage biomarkers [ Time Frame: We measure before and after 12 weeks strength training ]
- muscle regeneration and function [ Time Frame: We measure before and after 12-weeks strength training. ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00833157
|Principal Investigator:||Susanne G Petersen, MD||Bispebjerg Hospital, Institute of Sports Medicine Copenhagen|