Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

This study has been completed.

Sponsor:

Collaborators:

Lundbeck Foundation

Team Denmark

Danish Ministry of Culture

Anti Doping Danmark

The Danish Rheumatism Association

King Christian IX and Queen Louise Jubilee Bursary

Information provided by:

Bispebjerg Hospital

ClinicalTrials.gov Identifier:

NCT00832663

First received: January 29, 2009

Last updated: March 15, 2010

Last verified: March 2010

History of Changes

Purpose

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.

The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

Condition	Intervention
Muscle Damage	Drug: NSAID Drug: placebo


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Basic Science
Official Title:	The Influence of Blocking Inflammatory Activity in Vivo on Skeletal Muscle Regeneration in Humans

Further study details as provided by Bispebjerg Hospital:

Primary Outcome Measures:

Muscle regeneration [ Time Frame: 1 month ]

Secondary Outcome Measures:

Muscle strength [ Time Frame: 1 month ]


Enrollment:	32
Study Start Date:	April 2009
Study Completion Date:	December 2009
Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: NSAID receive NSAID	Drug: NSAID Effect of NSAID ingestion on muscle regeneration
Placebo Comparator: Placebo receive placebo	Drug: placebo receive placebo

Detailed Description:

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Eligibility


Ages Eligible for Study:	18 Years to 35 Years (Adult)
Sexes Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

male
healthy
does not exercise regularly

Exclusion Criteria:

displays contraindications for taking NSAID
well-trained

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00832663

Locations


Denmark
Bispebjerg Hospital
Copenhagen, NV, Denmark, 2400

Sponsors and Collaborators

Bispebjerg Hospital

Lundbeck Foundation

Team Denmark

Danish Ministry of Culture

Anti Doping Danmark

The Danish Rheumatism Association

King Christian IX and Queen Louise Jubilee Bursary

Investigators


Principal Investigator:	Abigail L Mackey, PhD	Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

More Information


Responsible Party:	Abigail Mackey, Institute of Sports Medicine Copenhagen
ClinicalTrials.gov Identifier:	NCT00832663 History of Changes
Other Study ID Numbers:	AM_P64_BBH H-D-2008-074
Study First Received:	January 29, 2009
Last Updated:	March 15, 2010

Keywords provided by Bispebjerg Hospital:


Muscle regeneration Satellite cells electrical stimulation eccentric contractions myogenic precursor cells

Additional relevant MeSH terms:


Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents	Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents

ClinicalTrials.gov processed this record on August 18, 2017

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