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Effects of Breastfeeding on Maternal Plasma Ghrelin and Peptide Tyrosine Tyrosine (PYY) Levels

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00831818
First Posted: January 29, 2009
Last Update Posted: June 1, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Medical University of Vienna
  Purpose
Weight retention after pregnancy contributes to increasing rates of obesity. There is evidence that breastfeeding is accompanied from changes in fat mobilisation and fat mass, nevertheless there are no data on the effects of breastfeeding on appetite-regulation. This study aims to investigate the direct effect of breastfeeding on the systemic levels of appetite-regulating hormones: ghrelin and PYY. Blood samples will be obtained at five time points (before, during and after breastfeeding) in ten mothers of healthy infants who breastfeed on demand and in ten mothers of healthy infants who do not breastfeed. All mothers will be fasting since 4 hours. The results will bring information on a possible direct effect of breastfeeding on appetite-regulatory hormones.

Condition
Breastfeeding

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effects of Breastfeeding on Maternal Plasma Ghrelin and PYY Levels

Resource links provided by NLM:


Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • ghrelin, PYY [ Time Frame: 60 minutes ]

Secondary Outcome Measures:
  • insulin, C-peptide, oxytocin, prolactin [ Time Frame: 60 minutes ]

Biospecimen Retention:   Samples With DNA
Whole blood

Estimated Enrollment: 20
Study Start Date: July 2008
Study Completion Date: November 2010
Primary Completion Date: May 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Mothers of healthy infants who breastfeed on demand
2
Mothers of healthy infants who do not breastfeed

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Mothers of healthy infants (babies aged 3-6 months).
Criteria

Inclusion Criteria:

Group 1:

  • healthy mothers (with normal BMI) fully breastfeeding their infants (aged 3 to 6 months) on demand
  • past normal pregnancy

Group 2:

  • healthy mothers (with normal BMI) that do not breastfeed their infants (aged 3 to 6 months)
  • past normal pregnancy

Exclusion Criteria (for both groups):

  • current endocrine and metabolic disease of the mother
  • cardiocirculatory, kidney or liver disease of the mother
  • infants having growth problems or any other current disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00831818


Locations
Austria
AKH, Medical University of Vienna
Vienna, Austria, A-1090
Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Martin Clodi, MD Division of Endocrinology and Metabolism, Medical University of Vienna
Study Chair: Anton Luger, MD Division of Endocrinology and Metabolism, Medical University of Vienna
  More Information

Responsible Party: Prof. Dr. Martin Clodi, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna
ClinicalTrials.gov Identifier: NCT00831818     History of Changes
Other Study ID Numbers: Breastfeeding_01
First Submitted: January 28, 2009
First Posted: January 29, 2009
Last Update Posted: June 1, 2011
Last Verified: May 2011

Keywords provided by Medical University of Vienna:
breastfeeding
ghrelin
PYY
appetite-regulation


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