Endothelial Function and Vein Graft Remodeling (EFVGR)
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ClinicalTrials.gov Identifier: NCT00831090
Verified April 2016 by University of California, San Francisco. Recruitment status was: Recruiting
The purpose of this study is to better understand why some vein bypass grafts develop narrowing. Evidence suggests that there is a relationship between inflammatory markers in the blood and the narrowing that occurs in blood vessels. In this study, we will look at inflammatory markers in the blood and how well the vein graft functions.
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Ages Eligible for Study:
22 Years to 89 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Vascular Surgery clinic
Age > 22 or < 90 years
Undergoing lower extremity (infrainguinal) bypass using autologous vein for the treatment of disabling claudication or critical limb ischemia secondary to chronic atherosclerotic occlusive disease
Able to understand, give, and take part in the consent process
Age < 22 or > 90 years
Grafts employing prosthetic or other non-autologous vein material in any part (e.g. composite grafts). [Patch angioplasty of inflow and outflow vessel permissible with any material]
Vasculitis, trauma, acute embolic disease as etiology of limb ischemia
History of diagnosed hypercoagulable state
Evidence of active infection - pneumonia, urinary tract, etc., requiring medical therapy
Evidence of significant local sepsis in foot or limb prior to bypass