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ClinicalTrials.gov Identifier: NCT00830375
Recruitment Status :
First Posted : January 27, 2009
Results First Posted : May 4, 2012
Last Update Posted : May 4, 2012
University of Minnesota - Clinical and Translational Science Institute
Information provided by (Responsible Party):
Jon E. Grant, University of Minnesota - Clinical and Translational Science Institute
This is an 8-week, open-labe study of memantine in the treatment of compulsive buying.
Condition or disease
The goal of the proposed study is to evaluate the efficacy of memantine in the treatment of compulsive buying. Sixteen subjects meeting criteria for compulsive buying will receive 8 weeks of open-label memantine. The hypothesis to be tested is that memantine will be effective and well tolerated in patients with compulsive buying. The proposed study will provide needed data on the treatment of a disabling disorder that currently lacks a clearly effective treatment.
Yale Brown Obsessive Compulsive Scale Modified for CB (CB-YBOCS) [ Time Frame: from study start to study end (8-weeks) and is Investigator rated ]
The CB-YBOCS is a reliable and valid, 10-item, clinician-administered scale that rates buying symptoms within the last seven days, on a severity scale from 0 to 4 for each item (total scores range from 0 to 40 with higher scores reflecting greater illness severity). Scores ranging from 0 to 10 reflect minimal or mild symptoms; scores from 11 to 20 suggest moderate symptoms; severe symptoms are associated with scores from 21 to 30; and scores greater than 30 reflect extreme buying symptoms
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Ages Eligible for Study:
18 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
men and women age 18-65
current CB using the clinician-administered Structured Clinical Interview for Compulsive buying (SCI-CB)
buying behavior within 2 weeks prior to enrollment
infrequent buying (i.e. less than one time per week) that does not meet proposed criteria for CB
unstable medical illness or clinically significant abnormalities on laboratory tests or physical examination at screen
history of seizures
myocardial infarction within 6 months
current pregnancy or lactation, or inadequate contraception in women of childbearing potential
a need for medication other than memantine with possible psychotropic effects or unfavorable interactions;
clinically significant suicidality;
current Axis I disorder determined by the SCID and SCID-compatible modules for impulse control disorders, except for nicotine dependence
lifetime history of bipolar disorder type I or II, dementia, schizophrenia, or any psychotic disorder determined by SCID
current or recent (past 3 months) DSM-IV substance abuse or dependence;
positive urine drug screen at screening
initiation of psychotherapy or behavior therapy within 3 months prior to study baseline
previous treatment with memantine
treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline