Echocardiographic Evaluation of Hypertensive Acute Pulmonary Edema
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|ClinicalTrials.gov Identifier: NCT00829855|
Recruitment Status : Completed
First Posted : January 27, 2009
Last Update Posted : March 5, 2013
Acute cardiogenic pulmonary edema (ACPE), one of the most severe forms of acute heart failure, represents 5% of hospital admissions. One of the most frequent phenomena encountered during ACPE is hypertensive crisis (hypertensive ACPE) but the mechanisms and causes of hypertensive ACPE are insufficiently understood. Few studies have evaluated the cardiac function during hypertensive ACPE, and these studies used only conventional echocardiography methods. New methods of evaluation of cardiac function in hypertensive ACPE (such as Tissue Doppler imaging) have not been used.
The objectives of this study are to evaluate presence and role of the following potential mechanisms of hypertensive ACPE: 1. acute myocardial dysfunction (systolic and diastolic); 2. silent transient myocardial ischemia; 3. acute mechanical left ventricular dyssynchrony; 4. dynamic mitral regurgitation; 5. inter-ventricular interaction. Conventional and Tissue Doppler echocardiography will be used to assess cardiac function.
|Condition or disease|
|Pulmonary Edema Hypertension|
|Study Type :||Observational|
|Actual Enrollment :||51 participants|
|Official Title:||Echocardiographic Evaluation of Hypertensive Acute Pulmonary Edema|
|Study Start Date :||May 2008|
|Actual Primary Completion Date :||May 2009|
|Actual Study Completion Date :||May 2009|
Patients with hypertensive (systolic blood pressure ≥160 mmHg) acute pulmonary edema, evaluated within 120 minutes after admittance.
The same patients from group 1 followed-up at 48 to 96 hours.
- acute myocardial dysfunction (systolic and diastolic) and/or dyssynchrony [ Time Frame: acute event and 48 to 96 h after the event ]
- surrogate markers of silent transient myocardial ischemia [ Time Frame: acute event and 48 to 96 h after the event ]
- dynamic mitral regurgitation [ Time Frame: acute event and 48 to 96 h after the event ]
- inter-ventricular interaction [ Time Frame: acute event and 48 to 96h after the event ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00829855
|Department of Cardiology, University and Emergency Hospital of Bucharest|
|Bucharest, Romania, 050098|
|Principal Investigator:||Mircea Cinteza, MD, PhD||University of Medicine and Pharmacy "Carol Davila" Bucharest|
|Principal Investigator:||Dragos Vinereanu, MD, PhD||University of Medicine and Pharmacy "Carol Davila" Bucharest|
|Study Chair:||Andrei D Margulescu, MD||University of Medicine and Pharmacy "Carol Davila" Bucharest|