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Observation of Initial Procalcitonin and the Clinical Course of Patients With Acute Respiratory Tract Infections

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00827060
First Posted: January 22, 2009
Last Update Posted: January 28, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hannover Medical School
  Purpose
Observation of the initial Procalcitonin values and the clinical course of consecutively included patients with Acute Respiratory Tract Infections at general medical practices in greater Hannover.

Condition
Respiratory Tract Infections

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Observation of the Initial Procalcitonin Values and the Clinical Course of Patients With Acute Respiratory Tract Infections at General Medical Practices in Greater Hannover

Further study details as provided by Hannover Medical School:

Enrollment: 702
Study Start Date: December 2006
Study Completion Date: September 2007
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
Detailed Description:

Primary endpoint:

  • initial Procalcitonin values of patients with Acute Respiratory Tract Infections

Secondary endpoints:

  • correlation of initial Procalcitonin values to classify Acute Respiratory Tract Infections
  • correlation of initial Procalcitonin values to subjective severity of Acute Respiratory Tract Infections
  • correlation of initial Procalcitonin values to antibiotic- prescriptions
  • correlation of initial Procalcitonin values to frequency of admission to hospital
  • correlation of initial Procalcitonin values to frequency of referrals (radiology, pneumology)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
primary care patients in 45 practices in greater Hannover
Criteria

Inclusion Criteria:

  • written informed consent
  • all types of respiratory tract infection according to investigator´s diagnosis

Exclusion Criteria:

  • pretreatment with antibiotics in the past 2 weeks
  • portal hypertension
  • Major surgeries or multiple trauma which require hospitalization, in previous 4 weeks
  • Autoimmune disease and systemic diseases (lupus erythematodes, wegener´s disease)
  • Peritoneal dialysis
  • Acute treated or recently operated medullary c-cell-carcinoma, SCLC, carcinoid
  • Other inflammatory diseases (e.g. urinary tract infection, pyelonephritis, pancreatitis
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00827060


Locations
Germany
Medical School Hannover, Department Pneumology
Hannover, Germany, 30625
Sponsors and Collaborators
Hannover Medical School
Investigators
Principal Investigator: Olaf Burkhardt, PD Dr. med. Medical School Hannover
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof. Dr. med. Tobias Welte
ClinicalTrials.gov Identifier: NCT00827060     History of Changes
Other Study ID Numbers: HannoverPro
First Submitted: January 21, 2009
First Posted: January 22, 2009
Last Update Posted: January 28, 2009
Last Verified: January 2009

Keywords provided by Hannover Medical School:
primary care
procalcitonin
acute respiratory tract infection

Additional relevant MeSH terms:
Infection
Communicable Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Calcitonin
Bone Density Conservation Agents
Physiological Effects of Drugs