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The Genetics of Diabetes in Southern California Chinese Americans

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2011 by University of California, Irvine.
Recruitment status was:  Recruiting
ClinicalTrials.gov Identifier:
First Posted: January 16, 2009
Last Update Posted: February 4, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Doris Duke Charitable Foundation
Information provided by:
University of California, Irvine
The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.

Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Metabolic Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort

Resource links provided by NLM:

Further study details as provided by University of California, Irvine:

Biospecimen Retention:   Samples With DNA
whole blood and serum

Estimated Enrollment: 500
Study Start Date: January 2006
Estimated Study Completion Date: November 2010
Estimated Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Individuals with diabetes
Individuals without diabetes

Detailed Description:
Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are currently recruiting Chinese Americans living in Southern California, espcially in Orange and Los Angeles Counties. We are particularly in need of Chinese American men and women with diabetes as well as healthy male controls. We can arrange for offsite weekend trips to cities within LA or Orange Counties for eligible groups of 10 or more people.

Inclusion Criteria:

  • Chinese or Taiwanese ancestry
  • Resident of Southern California
  • Age between 40 and 65
  • Both people with and without diabetes are welcome to enroll.

Exclusion Criteria:

  • Younger than 40 years or older than 65 years
  • Ancestry is not Chinese or Taiwanese
  • Not a resident of Southern California
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00824395

Contact: Julia Platt, MS 949-824-9232 jplatt@uci.edu
Contact: Shiqin Xu, PhD 949-892-7645 shiqinx@uci.edu

United States, California
UC Irvine General Clinical Research Center Recruiting
Irvine, California, United States, 92697
Contact: Julia Platt, MS    949-824-9232    jplatt@uci.edu   
Sponsors and Collaborators
University of California, Irvine
Doris Duke Charitable Foundation
Principal Investigator: Douglas C Wallace, PhD UC Irvine Center for Mitochondrial Medicine
  More Information

Responsible Party: Douglas C. Wallace, Ph.D / Principal Investigator, UC Irvine Center for Mitochondrial Medicine and Genetics
ClinicalTrials.gov Identifier: NCT00824395     History of Changes
Other Study ID Numbers: 2005-4675
First Submitted: January 15, 2009
First Posted: January 16, 2009
Last Update Posted: February 4, 2011
Last Verified: February 2011

Keywords provided by University of California, Irvine:
type 1
type 2
metabolic syndrome

Additional relevant MeSH terms:
Diabetes Mellitus
Metabolic Syndrome X
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pathologic Processes
Insulin Resistance
Autoimmune Diseases
Immune System Diseases