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The Genetics of Diabetes in Southern California Chinese Americans

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ClinicalTrials.gov Identifier: NCT00824395
Recruitment Status : Unknown
Verified February 2011 by University of California, Irvine.
Recruitment status was:  Recruiting
First Posted : January 16, 2009
Last Update Posted : February 4, 2011
Sponsor:
Collaborator:
Doris Duke Charitable Foundation
Information provided by:
University of California, Irvine

Brief Summary:
The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.

Condition or disease
Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Metabolic Syndrome

Detailed Description:
Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.

Study Type : Observational
Estimated Enrollment : 500 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort
Study Start Date : January 2006
Estimated Primary Completion Date : November 2010
Estimated Study Completion Date : November 2010


Group/Cohort
1
Individuals with diabetes
2
Individuals without diabetes



Biospecimen Retention:   Samples With DNA
whole blood and serum


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Ages Eligible for Study:   40 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are currently recruiting Chinese Americans living in Southern California, espcially in Orange and Los Angeles Counties. We are particularly in need of Chinese American men and women with diabetes as well as healthy male controls. We can arrange for offsite weekend trips to cities within LA or Orange Counties for eligible groups of 10 or more people.
Criteria

Inclusion Criteria:

  • Chinese or Taiwanese ancestry
  • Resident of Southern California
  • Age between 40 and 65
  • Both people with and without diabetes are welcome to enroll.

Exclusion Criteria:

  • Younger than 40 years or older than 65 years
  • Ancestry is not Chinese or Taiwanese
  • Not a resident of Southern California

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00824395


Contacts
Contact: Julia Platt, MS 949-824-9232 jplatt@uci.edu
Contact: Shiqin Xu, PhD 949-892-7645 shiqinx@uci.edu

Locations
United States, California
UC Irvine General Clinical Research Center Recruiting
Irvine, California, United States, 92697
Contact: Julia Platt, MS    949-824-9232    jplatt@uci.edu   
Sponsors and Collaborators
University of California, Irvine
Doris Duke Charitable Foundation
Investigators
Principal Investigator: Douglas C Wallace, PhD UC Irvine Center for Mitochondrial Medicine

Responsible Party: Douglas C. Wallace, Ph.D / Principal Investigator, UC Irvine Center for Mitochondrial Medicine and Genetics
ClinicalTrials.gov Identifier: NCT00824395     History of Changes
Other Study ID Numbers: 2005-4675
First Posted: January 16, 2009    Key Record Dates
Last Update Posted: February 4, 2011
Last Verified: February 2011

Keywords provided by University of California, Irvine:
diabetes
type 1
type 2
metabolic syndrome
mitochondria

Additional relevant MeSH terms:
Diabetes Mellitus
Syndrome
Metabolic Syndrome X
Diabetes Mellitus, Type 2
Diabetes Mellitus, Type 1
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Disease
Pathologic Processes
Insulin Resistance
Hyperinsulinism
Autoimmune Diseases
Immune System Diseases