The Genetics of Diabetes in Southern California Chinese Americans
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| ClinicalTrials.gov Identifier: NCT00824395 |
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Recruitment Status : Unknown
Verified February 2011 by University of California, Irvine.
Recruitment status was: Recruiting
First Posted : January 16, 2009
Last Update Posted : February 4, 2011
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Sponsor:
University of California, Irvine
Collaborator:
Doris Duke Charitable Foundation
Information provided by:
University of California, Irvine
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Brief Summary:
The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.
| Condition or disease |
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| Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Metabolic Syndrome |
Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.
| Study Type : | Observational |
| Estimated Enrollment : | 500 participants |
| Observational Model: | Case Control |
| Time Perspective: | Cross-Sectional |
| Official Title: | Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort |
| Study Start Date : | January 2006 |
| Estimated Primary Completion Date : | November 2010 |
| Estimated Study Completion Date : | November 2010 |
Resource links provided by the National Library of Medicine
Genetics Home Reference related topics:
Type 1 diabetes
MedlinePlus related topics:
Metabolic Syndrome
| Group/Cohort |
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1
Individuals with diabetes
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2
Individuals without diabetes
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Biospecimen Retention: Samples With DNA
whole blood and serum
Information from the National Library of Medicine
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| Ages Eligible for Study: | 40 Years to 65 Years (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
We are currently recruiting Chinese Americans living in Southern California, espcially in Orange and Los Angeles Counties. We are particularly in need of Chinese American men and women with diabetes as well as healthy male controls. We can arrange for offsite weekend trips to cities within LA or Orange Counties for eligible groups of 10 or more people.
Criteria
Inclusion Criteria:
- Chinese or Taiwanese ancestry
- Resident of Southern California
- Age between 40 and 65
- Both people with and without diabetes are welcome to enroll.
Exclusion Criteria:
- Younger than 40 years or older than 65 years
- Ancestry is not Chinese or Taiwanese
- Not a resident of Southern California
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00824395
Contacts
| Contact: Julia Platt, MS | 949-824-9232 | jplatt@uci.edu | |
| Contact: Shiqin Xu, PhD | 949-892-7645 | shiqinx@uci.edu |
Locations
| United States, California | |
| UC Irvine General Clinical Research Center | Recruiting |
| Irvine, California, United States, 92697 | |
| Contact: Julia Platt, MS 949-824-9232 jplatt@uci.edu | |
Sponsors and Collaborators
University of California, Irvine
Doris Duke Charitable Foundation
Investigators
| Principal Investigator: | Douglas C Wallace, PhD | UC Irvine Center for Mitochondrial Medicine |
| Responsible Party: | Douglas C. Wallace, Ph.D / Principal Investigator, UC Irvine Center for Mitochondrial Medicine and Genetics |
| ClinicalTrials.gov Identifier: | NCT00824395 History of Changes |
| Other Study ID Numbers: |
2005-4675 |
| First Posted: | January 16, 2009 Key Record Dates |
| Last Update Posted: | February 4, 2011 |
| Last Verified: | February 2011 |
Keywords provided by University of California, Irvine:
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diabetes type 1 type 2 metabolic syndrome mitochondria |
Additional relevant MeSH terms:
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Diabetes Mellitus Syndrome Metabolic Syndrome X Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 1 Glucose Metabolism Disorders Metabolic Diseases |
Endocrine System Diseases Disease Pathologic Processes Insulin Resistance Hyperinsulinism Autoimmune Diseases Immune System Diseases |