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The Genetics of Diabetes in Southern California Chinese Americans

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ClinicalTrials.gov Identifier: NCT00824395
Recruitment Status : Withdrawn (Non applicable clinical trial)
First Posted : January 16, 2009
Last Update Posted : January 25, 2021
Sponsor:
Collaborator:
Doris Duke Charitable Foundation
Information provided by (Responsible Party):
University of California, Irvine

Study Description
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Brief Summary:
The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.

Condition or disease
Type 1 Diabetes Type 2 Diabetes Metabolic Syndrome

Detailed Description:
Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.
Study Design
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Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort
Study Start Date : January 2006
Actual Primary Completion Date : January 2006
Actual Study Completion Date : January 2006

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Group/Cohort
1
Individuals with diabetes
2
Individuals without diabetes


Outcome Measures
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Biospecimen Retention:   Samples With DNA
whole blood and serum

Eligibility Criteria
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Ages Eligible for Study:   40 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We are currently recruiting Chinese Americans living in Southern California, espcially in Orange and Los Angeles Counties. We are particularly in need of Chinese American men and women with diabetes as well as healthy male controls. We can arrange for offsite weekend trips to cities within LA or Orange Counties for eligible groups of 10 or more people.
Criteria

Inclusion Criteria:

  • Chinese or Taiwanese ancestry
  • Resident of Southern California
  • Age between 40 and 65
  • Both people with and without diabetes are welcome to enroll.

Exclusion Criteria:

  • Younger than 40 years or older than 65 years
  • Ancestry is not Chinese or Taiwanese
  • Not a resident of Southern California
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00824395


Locations
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United States, California
UC Irvine General Clinical Research Center
Irvine, California, United States, 92697
Sponsors and Collaborators
University of California, Irvine
Doris Duke Charitable Foundation
Investigators
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Principal Investigator: Douglas C Wallace, PhD UC Irvine Center for Mitochondrial Medicine
More Information
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Responsible Party: University of California, Irvine
ClinicalTrials.gov Identifier: NCT00824395    
Other Study ID Numbers: 2005-4675
First Posted: January 16, 2009    Key Record Dates
Last Update Posted: January 25, 2021
Last Verified: January 2021
Keywords provided by University of California, Irvine:
diabetes
type 1
type 2
metabolic syndrome
mitochondria
Additional relevant MeSH terms:
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Diabetes Mellitus
Metabolic Syndrome
Syndrome
Disease
Pathologic Processes
 Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Insulin Resistance
Hyperinsulinism