Alveolar Macrophage Proteomics in HIV-associated Emphysema (HIVE)
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|ClinicalTrials.gov Identifier: NCT00823927|
Recruitment Status : Unknown
Verified April 2015 by Philip Diaz, Ohio State University.
Recruitment status was: Active, not recruiting
First Posted : January 16, 2009
Last Update Posted : April 22, 2015
|Condition or disease|
|HIV Emphysema HIV Infections|
To delineate the natural history of HIV associated emphysema in the HAART era. To compare the alveolar macrophage proteomes from HIV-seropositive smokers with emphysema to the alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers.
To establish whether coinfection with HIV and Hepatitis C results in accelerated lung disease manifested by decrements in forced expiratory volume and carbon monoxide diffusing capacity.
|Study Type :||Observational|
|Actual Enrollment :||365 participants|
|Observational Model:||Case Control|
|Official Title:||Alveolar Macrophage Proteomics in HIV-associated Emphysema|
|Study Start Date :||March 2006|
|Estimated Primary Completion Date :||December 2015|
|Estimated Study Completion Date :||December 2015|
HIV smokers with emphysema
HIV smokers without emphysema
- examine the natural history of smoking related lung damage in patients with HIV [ Time Frame: 3 years ]HIV-Seropositive individuals are at increased risk of developing pulmonary emphysema (1,2). With improved therapy for HIV, and increased life expectancy in this population with a high smoking prevalence, chronic obstructive pulmonary disease (COPD) may assume an increasingly important role with respect to health related quality of life and medical complications. This research will provide a unique opportunity to examine the natural history of smoking related lung damage in patients with HIV infection. In addition, this research will involve sampling of lung cells to determine if there are unique proteins present that may be related to the increased risk of emphysema in this population. This may shed important insight into how the lung responds to injury and how it repairs itself. If critical proteins can be identified, treatment strategies may eventually be developed to either decrease proteins causing injury or increase protective proteins.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00823927
|United States, Ohio|
|The Ohio State University|
|Columbus, Ohio, United States, 43026|
|Principal Investigator:||Philip T Diaz, MD||Ohio State University|