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Immune Status of Elderly Population Admitted in an Acute Geriatric Unit

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00823589
First Posted: January 15, 2009
Last Update Posted: February 25, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Assistance Publique Hopitaux De Marseille
  Purpose

Ageing is associated with vulnerability against infections leading to increased morbidity with risk of death. Innate and adaptive immunities are altered with ageing responsible of deficits in immune response against pathogens and after vaccination, and favouring the elderly vulnerability against a new pathogen with increased bacterial, viral, and fungal infections.

If immunity has been widely studied in immunosenescence, there are few prospective, comparative studies with elderly ill patients. Moreover among these studies, pathologies are not well defined.

The main objective of our project is to compare the immune state of elderly hospitalised subjects in an acute geriatric unit to the immune state of elderly healthy subjects selected with strict criteria, in order to precise the impact of polypathology and of various pathologies on immunity state.


Condition Intervention
Aging Other: Blood test and clinical test

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: Immune Status of Elderly Population Admitted in an Acute Geriatric Unit

Further study details as provided by Assistance Publique Hopitaux De Marseille:

Primary Outcome Measures:
  • compare the immune state of elderly hospitalised subjects in an acute geriatric unit to the immune state of elderly healthy subjects [ Time Frame: 2 years ]

Enrollment: 78
Study Start Date: January 2009
Study Completion Date: February 2012
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: pathological group
pathological group
Other: Blood test and clinical test
Blood test and clinical test
Experimental: healthy aged
healthy aged
Other: Blood test and clinical test
Blood test and clinical test

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   75 Years and older   (Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Subject of 75 or more years old, female or male
  • Subject admitted in the service of short stay gériatrique of the hospital Holy Marguerite, whatever is the motive for admittance
  • Subject not being under supervision(guardianship), nor guardianship
  • Subject benefiting from a benefit system
  • Subject having given its assent of participation or for which the reliable person gave her assent in the case of vulnerable person

Exclusion Criteria:

  • Subject of less than 75 years old
  • Subject refusing to participate in the study or for whom(which) the reliable person refuses the participation of the subject
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00823589


Locations
France
HOPITAL DE SAINTE MARGUERITE Service de Gériatrie Sud
Marseille, Paca, France
Sponsors and Collaborators
Assistance Publique Hopitaux De Marseille
Investigators
Principal Investigator: ELODIE CRETEL Assistance Publique Hopitaux De Marseille
  More Information

Responsible Party: Assistance Publique Hopitaux De Marseille
ClinicalTrials.gov Identifier: NCT00823589     History of Changes
Other Study ID Numbers: 2008 -21
First Submitted: January 14, 2009
First Posted: January 15, 2009
Last Update Posted: February 25, 2014
Last Verified: February 2014

Keywords provided by Assistance Publique Hopitaux De Marseille:
ELDERLY POPULATION