Bone Marrow Autotransplantation in Type 1 Diabetes
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This project evaluates the effectiveness of the administration of autologous bone marrow blood in patients with brittle type 1 diabetes mellitus to restore insulin secretion. After mobilization of hematopoietic progenitors (G-CSF) during 3 days, 50 to 90 mL of bone marrow blood will be obtained by multifunction in the posterior iliac crest. The material obtained will be implanted into the pancreas through the magna pancreatic artery after femoral catheterization.
Condition or disease
Type 1 Diabetes Mellitus
Biological: administration of autologous bone marrow blood
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 50 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
diabetes type 1 patients
18 to 50 years of age
more than 5 years of evolution of the disease
brittle diabetes (HbA1c > 8.5 % with intensified treatment or severe hypoglycemia episodes