The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery
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|ClinicalTrials.gov Identifier: NCT00821522|
Recruitment Status : Unknown
Verified April 2010 by Maine Medical Center Research Institute.
Recruitment status was: Enrolling by invitation
First Posted : January 13, 2009
Last Update Posted : July 22, 2010
|Condition or disease||Intervention/treatment||Phase|
|Acute Kidney Insufficiency Acute Renal Insufficiency Acute Kidney Injury Ischemic Preconditioning||Procedure: Remote Ischemic Preconditioning||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||120 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery|
|Study Start Date :||November 2008|
|Estimated Primary Completion Date :||March 2010|
|Estimated Study Completion Date :||May 2010|
|Active Comparator: Preconditioning||
Procedure: Remote Ischemic Preconditioning
Three 5-minute intervals of leg ischemia induced by tourniquet inflation, prior to initiation of cardiopulmonary bypass.
No Intervention: Control
Standard clinical management during cardiac surgery.
- Incidence of acute kidney injury, after surgery, as defined by elevation in serum creatinine greater than or equal to 0.3 mg/dl. [ Time Frame: 48 hours after surgery. ]
- Oliguria. [ Time Frame: 12 hours after surgery. ]
- Incidence of acute kidney injury as defined by post-operative elevation in NGAL. [ Time Frame: 3 hours after cardiopulmonary bypass. ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00821522
|United States, Maine|
|Maine Medical Center|
|Portland, Maine, United States, 04102|
|Principal Investigator:||Robert F Zimmerman, MD||Maine Medical Center Research Institute|