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Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

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ClinicalTrials.gov Identifier: NCT00818506
Recruitment Status : Completed
First Posted : January 7, 2009
Last Update Posted : November 21, 2012
Information provided by (Responsible Party):

Study Description
Brief Summary:
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

Condition or disease
Depression Major Depressive Disorder Cardiovascular Disease Coronary Artery Disease

Study Design

Study Type : Observational
Actual Enrollment : 55 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder
Study Start Date : March 2009
Study Completion Date : June 2012
Groups and Cohorts

Late onset MDD
Patients with major depressive disorder between 50 and 70 years of age that did not suffer from depression before the age of 50.
Healthy controls (matched for age, sex, and tobacco use status)

Outcome Measures

Biospecimen Retention:   Samples With DNA
Whole Blood

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Psychiatric treatment facilities (e.g. psychiatric hospital, private psychiatrist).


  • Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.
  • Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).
  • Age 50-70 years.
  • Written informed consent.
  • Caucasian.


  • Known, or anamnestic/objective signs of, organic brain disease.
  • Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).
  • Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.
  • Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).
  • Subject to force of law according to the danish law on psychiatry.
  • Present risk of suicide.
  • Previous cranial trauma resulting in unconsciousness for more than 2 minutes.
  • Medical history of renal failure.
  • Other conditions which contraindicate specific procedures in the project.
  • Other conditions deemed to prevent the subject from completing the examination program.
  • Does not want to participate.
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00818506

Center of Psychiatric Research, Aarhus University Hospital
Aarhus, Denmark, 8200
Sponsors and Collaborators
University of Aarhus
The Ministry of Science, Technology and Innovation, Denmark
Vejle Hospital
Danish National Research Foundation
Aarhus University Hospital
Augustinus Fonden
Study Director: Poul Videbech, Professor, M.D., Dr.Med. Center of Psychiatric Research, Aarhus University Hospital
More Information

Additional Information:
Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00818506     History of Changes
Other Study ID Numbers: CPF-TAD-1
First Posted: January 7, 2009    Key Record Dates
Last Update Posted: November 21, 2012
Last Verified: November 2012

Keywords provided by University of Aarhus:
Major depressive disorder
Coronary artery disease
White Matter Hyperintensities
White Matter Lesions
Coronary artery calcification

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Cardiovascular Diseases
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Behavioral Symptoms
Mood Disorders
Mental Disorders
Heart Diseases
Arterial Occlusive Diseases
Vascular Diseases