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Impact of a Sleep Debt in Middle-Aged and Older Adults (PPG)

This study has been completed.
Information provided by (Responsible Party):
University of Chicago Identifier:
First received: January 5, 2009
Last updated: January 9, 2017
Last verified: January 2017

This project has 6 aims.

  1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
  2. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
  3. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
  4. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
  5. To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
  6. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Condition Intervention
Sleep Restriction
Other: Sleep restriction

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Official Title: Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults

Further study details as provided by University of Chicago:

Primary Outcome Measures:
  • Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery. [ Time Frame: Completion of 23 day study ]

Enrollment: 72
Study Start Date: April 2005
Study Completion Date: May 2008
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Normal (8 hours) sleep time
Subjects are studied under normal sleep time conditions.
Experimental: Sleep restriction

Sleep restriction to 4 hours of sleep per night.

Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.

Other: Sleep restriction
Sleep restriction.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • normal weight
  • healthy
  • age 18-75 old

Exclusion Criteria:

  • sleep disorder
  • irregular life habits (shift workers, travelers)
  • smokers
  • on medication
  • consumption of > 2 alcohol or caffeinated beverages/day
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00817700

United States, Illinois
The University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Principal Investigator: Eve Van Cauter, PhD University of Chicago
  More Information

Responsible Party: University of Chicago Identifier: NCT00817700     History of Changes
Other Study ID Numbers: #13159A
5P01AG011412 ( US NIH Grant/Contract Award Number )
Study First Received: January 5, 2009
Last Updated: January 9, 2017

Keywords provided by University of Chicago:
young adults
middle-age adults
older adults processed this record on May 25, 2017