Impact of a Sleep Debt in Middle-Aged and Older Adults (PPG)
This project has 6 aims.
- To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
- To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
- To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
- To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
- To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
- To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
|Official Title:||Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults|
- Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery. [ Time Frame: Completion of 23 day study ]
|Study Start Date:||April 2005|
|Study Completion Date:||May 2008|
|Primary Completion Date:||November 2007 (Final data collection date for primary outcome measure)|
No Intervention: Normal (8 hours) sleep time
Subjects are studied under normal sleep time conditions.
Experimental: Sleep restriction
Sleep restriction to 4 hours of sleep per night.
Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.
Other: Sleep restriction
Please refer to this study by its ClinicalTrials.gov identifier: NCT00817700
|United States, Illinois|
|The University of Chicago|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||Eve Van Cauter, PhD||University of Chicago|