Impact of a Sleep Debt in Middle-Aged and Older Adults (PPG)
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|ClinicalTrials.gov Identifier: NCT00817700|
Recruitment Status : Completed
First Posted : January 6, 2009
Last Update Posted : January 11, 2017
This project has 6 aims.
- To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
- To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
- To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
- To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
- To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
- To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.
|Condition or disease||Intervention/treatment||Phase|
|Sleep Restriction||Other: Sleep restriction||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||72 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults|
|Study Start Date :||April 2005|
|Actual Primary Completion Date :||November 2007|
|Actual Study Completion Date :||May 2008|
No Intervention: Normal (8 hours) sleep time
Subjects are studied under normal sleep time conditions.
Experimental: Sleep restriction
Sleep restriction to 4 hours of sleep per night.
Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.
Other: Sleep restriction
- Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery. [ Time Frame: Completion of 23 day study ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00817700
|United States, Illinois|
|The University of Chicago|
|Chicago, Illinois, United States, 60637|
|Principal Investigator:||Eve Van Cauter, PhD||University of Chicago|