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Impact of a Sleep Debt in Middle-Aged and Older Adults (PPG)

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ClinicalTrials.gov Identifier: NCT00817700
Recruitment Status : Completed
First Posted : January 6, 2009
Last Update Posted : January 11, 2017
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:

This project has 6 aims.

  1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
  2. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
  3. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
  4. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
  5. To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
  6. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Condition or disease Intervention/treatment
Sleep Restriction Other: Sleep restriction

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 72 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults
Study Start Date : April 2005
Primary Completion Date : November 2007
Study Completion Date : May 2008
Arms and Interventions

Arm Intervention/treatment
No Intervention: Normal (8 hours) sleep time
Subjects are studied under normal sleep time conditions.
Experimental: Sleep restriction

Sleep restriction to 4 hours of sleep per night.

Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.

Other: Sleep restriction
Sleep restriction.


Outcome Measures

Primary Outcome Measures :
  1. Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery. [ Time Frame: Completion of 23 day study ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • normal weight
  • healthy
  • age 18-75 old

Exclusion Criteria:

  • sleep disorder
  • irregular life habits (shift workers, travelers)
  • smokers
  • on medication
  • consumption of > 2 alcohol or caffeinated beverages/day
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00817700


Locations
United States, Illinois
The University of Chicago
Chicago, Illinois, United States, 60637
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: Eve Van Cauter, PhD University of Chicago
More Information

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00817700     History of Changes
Other Study ID Numbers: #13159A
5P01AG011412 ( U.S. NIH Grant/Contract )
First Posted: January 6, 2009    Key Record Dates
Last Update Posted: January 11, 2017
Last Verified: January 2017

Keywords provided by University of Chicago:
Sleep
young adults
middle-age adults
older adults