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Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat (FEIGH)

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ClinicalTrials.gov Identifier: NCT00817440
Recruitment Status : Completed
First Posted : January 6, 2009
Last Update Posted : January 11, 2011
Sponsor:
Information provided by:
University of Aarhus

Brief Summary:

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.

In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.


Condition or disease Intervention/treatment Phase
Healthy Other: Exercise Other: Fasting Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 8 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat
Study Start Date : December 2008
Actual Primary Completion Date : May 2009

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U.S. FDA Resources

Arm Intervention/treatment
No Intervention: Control
control: muscle and fat biopsies and basal aminoacid and glucose turnover
Experimental: Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
Other: Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
Experimental: Fasting
3 days of fasting and then the same as arm 1
Other: Fasting
3 days of fasting and then the same as arm 1



Primary Outcome Measures :
  1. Growth hormone and insulin signal pathways [ Time Frame: 30 min ]

Secondary Outcome Measures :
  1. aminoacid and glucose turnover [ Time Frame: 4 hours ]


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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men
  • Body mass index (BMI) 20-26
  • age 18-45 years

Exclusion Criteria:

  • any kind of disease
  • any use of medicine

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00817440


Locations
Denmark
Aarhus sygehus
Aarhus, Jylland, Denmark, 8000
Sponsors and Collaborators
University of Aarhus

Responsible Party: Mikkel Vendelbo MD, endokrinologiskforskningslaboratorium M, Aarhus sygehus
ClinicalTrials.gov Identifier: NCT00817440     History of Changes
Other Study ID Numbers: 16.12.2008
First Posted: January 6, 2009    Key Record Dates
Last Update Posted: January 11, 2011
Last Verified: January 2011

Keywords provided by University of Aarhus:
growth hormone insulin signaltransduction signalpathways
growth hormone and insulin signalpathways

Additional relevant MeSH terms:
Insulin, Globin Zinc
Insulin
Hypoglycemic Agents
Physiological Effects of Drugs