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Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00816738
First Posted: January 5, 2009
Last Update Posted: January 5, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
To evaluate the clinical outcomes in patients with recurrent corneal erosions who received anterior stromal puncture by use of neodymium:yttrium-aluminum-garnet (Nd:YAG) laser.

Condition
Recurrent Corneal Erosion Trauma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • Cure rate of recurrent corneal erosions (frequency of attack and numbers of Nd: YAG laser treatment), intensity of pain relief and visual acuity. [ Time Frame: Before treatment, weekly after the treatment, and monthly after symptom relief ]

Enrollment: 33
Study Start Date: January 2008
Study Completion Date: March 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Detailed Description:

Participants: From 2000 to 2005, thirty-three eyes in 33 patients with unilaterally recurrent corneal erosions who showed poor response to conservative managements and were treated with Nd:YAG laser were studied.

Intervention: Anterior corneal stromal puncture with Nd:YAG laser was performed in the loosened epithelium or epithelial defect area. The causes and frequency of corneal erosions and the spot numbers and total energy of the Nd:YAG laser were recorded. Slit-lamp biomicroscopic examination, refraction, corneal topography, and times of laser were reviewed. A questionnaire regarding the preoperative and postoperative difference in the intensity of pain and frequency of corneal erosion was provided.

Main Outcome Measures: Rate of recurrence and pain assessment by numerical rating scale.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 71 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
to evaluate the clinical outcomes after anterior stromal puncture with Nd:YAG laser in a consecutive series of 33 eyes in 33 patients with unilaterally recurrent corneal erosion.
Criteria

Inclusion Criteria:

  • patients with recurrent corneal erosions who showed poor response to conservative managements and were treated with Nd:YAG laser.

Exclusion Criteria:

  • Slit-lamp biomicroscopic examination in both eyes of patient showed any evidence of anterior basement membrane dystrophy.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00816738


Locations
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Yu-Chih Ho, MD National Taiwan University Hospital
Principal Investigator: Tzu-Hsun Tsai, MD National Taiwan University Hospital
Principal Investigator: Tzu-Yun Tsai, MD National Taiwan University Hospital
  More Information

Responsible Party: Yu-Chih Hou/Department of Ophthalmology, National Taiwan University Hospital, Organization: Department of Ophthalmology, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00816738     History of Changes
Other Study ID Numbers: 200801035R
First Submitted: August 31, 2008
First Posted: January 5, 2009
Last Update Posted: January 5, 2009
Last Verified: December 2008

Keywords provided by National Taiwan University Hospital:
Nd: YAG laser
recurrent corneal erosions
trauma
anterior stromal puncture